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Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however, pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children with suspected respiratory infections.
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http://dx.doi.org/10.1093/jpids/piae023 | DOI Listing |
Case Rep Med
September 2025
Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Oral and maxillofacial space infection (OMSI) progresses rapidly, and when combined with diabetic ketoacidosis (DKA), it can become a serious and life-threatening condition. Cases of OMSI with concurrent DKA are relatively rare. This case report describes a young man who developed OMSI caused by methicillin-resistant in the setting of DKA.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.
View Article and Find Full Text PDFMed Lett Drugs Ther
September 2025
Biochem Pharmacol
September 2025
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, 310015 Hangzhou, China. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly virulent and drug-resistant pathogen frequently causing bacterial pneumonia. Currently, there are limited effective treatments available due to the rapidly evolving resistance of bacteria. Therefore, there is an urgent need to develop novel therapies that focus on host-pathogen interactions.
View Article and Find Full Text PDFInfection
September 2025
Research Unit for Environment, Work and Health, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, Aarhus C, DK-8000, Denmark.
Background: Livestock-MRSA (methicillin-resistant Staphylococcus aureus) can cause infections in persons without known contact to livestock, but the route of transmission is unclear. We investigated whether the risk of livestock-MRSA infection among persons with no known contact to livestock is associated with the number of pig farms near the home, and whether this association is affected by the upwind/downwind location of the farms.
Methods: Register-based case-control study of 518 persons from Denmark with clinical infections with livestock-MRSA in 2016-2021 and no known exposure to livestock, and 4,944 matched controls.