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Article Abstract
: The gene and its polymorphisms were identified as novel players in the regulation of food intake, potentially leading to obesity (OBE) and altered eating behaviors. Naltrexone/bupropion SR (NB) showed good efficacy and tolerability for treating OBE and altered eating behaviors associated with binge eating disorder (BED). This prospective study investigates the influence of gene polymorphism on NB treatment response in OBE and BED. : Body mass index (BMI), eating (EDE-Q, BES, NEQ, GQ, Y-FAS 2.0) and general psychopathology (BDI, STAI-S) were evaluated at baseline (t0) and after 16 weeks (t1) of NB treatment in patients with OBE and BED (Group 1; = 22) vs. patients with OBE without BED (Group 2; = 20). Differences were evaluated according to the rs757081 gene polymorphism. : polymorphism was equally distributed between groups. Although weight at t0 was higher in Group 1, weight loss was similar at t1 in both groups. BMI was not influenced by polymorphism. In Group 1, the CG-genotype reported significant improvement in eating psychopathology while the GG-genotype reported improvement only for FA. No differences were observed in Group 2. : Patients diagnosed with BED and treated with NB exhibited a more favorable treatment response within the CG-genotype of the polymorphism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887296 | PMC |
| http://dx.doi.org/10.3390/biomedicines12020451 | DOI Listing |
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