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Why, when, and how to consider external control cohorts in pediatric brain tumor clinical trials.
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Quinoline as a Photochemical Toolbox: From Substrate to Catalyst and Beyond.
Acc Chem Res
September 2025
Department of Chemistry, FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street W, Montréal, Québec H3A 0B8, Canada.
ConspectusMolecular photochemistry, by harnessing the excited states of organic molecules, provides a platform fundamentally distinct from thermochemistry for generating reactive open-shell or spin-active species under mild conditions. Among its diverse applications, the resurgence of the Minisci-type reaction, a transformation historically reliant on thermally initiated radical conditions, has been fueled by modern photochemical strategies with improved efficiency and selectivity. Consequently, the photochemical Minisci-type reaction ranks among the most enabling methods for C()-H functionalizations of heteroarenes, which are of particular significance in medicinal chemistry for the rapid diversification of bioactive scaffolds.
View Article and Find Full Text PDFInfluence of ultrafiltration conditions on the unbound fraction of phenytoin and valproic acid.
Eur J Clin Pharmacol
September 2025
Department of Hospital Pharmacy, Meander Medical Centre, Amersfoort, the Netherlands.
Purpose: This study was designed to analyse the influence of temperature, pH and storage time on unbound fractions of PHT and VPA.
Methods: The influence of ultrafiltration (UF) temperature on measured unbound fractions of PHT and VPA in spiked samples was evaluated in a single laboratory experiment and in data from a national external quality control (EQC) database. The influence of pH adjustment with phosphate buffered saline (PBS) on measured unbound fractions of PHT and VPA was investigated in patient samples.
[Minimally invasive surgery for liver echinococcosis].
Khirurgiia (Mosk)
September 2025
Dagestan State Medical University, Makhachkala, Russia.
Objective: To analyze the effectiveness of minimally invasive surgery for small and medium sized liver cysts.
Material And Methods: We used minimally invasive technologies in 331 patients with echinococcal liver cysts (small cysts (<3.5 cm) - 49 (14.
Risk Stratification of Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy: Arrhythmogenic Substrate Assessment in Cardiac MRI.
Radiology
September 2025
Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background MRI-derived arrhythmogenic substrate, including late gadolinium enhancement (LGE) and extracellular volume fraction (ECV), is indicative of sudden cardiac death (SCD) risk in nonischemic dilated cardiomyopathy (DCM). The relative prognostic value of LGE and ECV remains unclear. Purpose To evaluate the performance of LGE and T1 mapping in predicting SCD in patients with DCM and to explore clinical implementation.
View Article and Find Full Text PDFDesign and Dosimetric Analysis of a Whole-Body Exposure Setup for Investigating Possible Effects of 50 Hz Magnetic Fields on Sleep and Markers of Alzheimer's Disease.
Bioelectromagnetics
September 2025
Competence Centre of Sleep Medicine, Charité -Universitaetsmedizin Berlin, Berlin, Germany.
A new whole-body exposure facility for a randomized, double-blind, cross-over provocation study investigating possible effects of 50 Hz magnetic field exposure on sleep and markers of Alzheimer's disease has been developed and dosimetrically analyzed. The exposure facility was custom-tailored for the sleep laboratory where the study was carried out and enables magnetic flux densities of up to 30 μT with a maximum field inhomogeneity of less than ± 20%. Exposure is applied fully software-controlled and in a blinded and randomized manner.
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