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Article Abstract
Anithiactin D (), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes sp. 10A085. The chemical structure of was elucidated based on the interpretation of NMR and MS data. The absolute configuration of was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D () significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus , which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.
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| http://dx.doi.org/10.3390/md22020088 | DOI Listing |
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