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This article introduces an integrated and biologically inspired theory of decision making, motor preparation, and motor execution. The theory is formalized as an extension of the diffusion model, in which diffusive accumulated evidence from the decision-making process is continuously conveyed to motor areas of the brain that prepare the response, where it is smoothed by a mechanism that approximates a Kalman-Bucy filter. The resulting motor preparation variable is gated prior to reaching agonist muscles until it exceeds a particular level of activation. We tested this gated cascade diffusion model by continuously probing the electrical activity of the response agonists through electromyography in four choice tasks that span a variety of domains in cognitive sciences, namely motion perception, numerical cognition, recognition memory, and lexical knowledge. The model provided a good quantitative account of behavioral and electromyographic data and systematically outperformed previous models. This work represents an advance in the integration of processes involved in simple decisions and sheds new light on the interplay between decision and motor systems. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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http://dx.doi.org/10.1037/rev0000464 | DOI Listing |
Behav Res Methods
September 2025
Department of Psychology, University of Basel, Basel, Switzerland.
Over the past several decades, decision-making research has been dominated by the study of binary choice tasks, with key models assuming that people remain equally cautious regardless of how long they have spent on the choice problem. Recent research has begun to place a greater focus on studying tasks with a continuous-response scale, as well as models that allow for decreases in caution over decision time; however, these research topics have remained separate from one another. For instance, proposed models of continuous-response scales have assumed constant caution over time, and studies investigating whether caution decreases over time have focused on binary choice tasks.
View Article and Find Full Text PDFPharm Res
September 2025
Mechanical and Aerospace Engineering Department, University of Texas at Arlington, 500 W First St, Rm 211, Arlington, TX, 76019, USA.
Objective: A fundamental understanding of drug diffusion and binding processes is critical for the design and optimization of a wide variety of drug delivery devices. Most of the past literature assume binding to occur uniformly throughout the tissue, or, at best, in specific layers of a multilayer tissue. However, in many realistic scenarios, such as in cancer-targeting drugs, drug binding occurs in discrete irregularly shaped regions.
View Article and Find Full Text PDFJ Math Biol
September 2025
School of Mathematical Sciences and Institute of Natural Sciences, MOE-LSC, CMA-Shanghai, Shanghai Jiao Tong University, Shanghai, China.
It has been noticed that when the waiting time distribution exhibits a transition from an intermediate time power-law decay to a long-time exponential decay in the continuous time random walk model, a transition from anomalous diffusion to normal diffusion can be observed at the population level. However, the mechanism behind the transition of waiting time distribution is rarely studied. In this paper, we provide one possible mechanism to explain the origin of such a transition.
View Article and Find Full Text PDFNat Nanotechnol
September 2025
Department of Bioengineering, Rice University, Houston, TX, USA.
Maintaining safe and potent drug levels in vivo is challenging. Multidomain peptides assemble into supramolecular hydrogels with a well-defined, highly porous nanostructure that makes them attractive for drug delivery. However, their ability to extend release is typically limited by rapid drug diffusion.
View Article and Find Full Text PDFBiosystems
September 2025
IVIRMA Global Research Alliance, The Health Research Institute La Fe (IIS La Fe), Edificio Biopolo. Av. Fernando Abril Martorell, 106 - Torre A, Planta 1, Valencia, 46026, Spain; Rey Juan Carlos University, Department of Medical Specialties and Public Health, Edificio Departamental II. Av. de Atenas
Cellular aging associated with telomeric shortening plays an important role in female fertility. In addition to natural decline, due to the loss of telomeric repeats during cell division, other factors such oxidative stress (OS), accelerate telomere shortening by causing a dramatic loss of telomeric repeats. Thus, mathematical models to better understand the accelerated aging leading to infertility are lacking in the literature.
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