98%
921
2 minutes
20
PomBase (https://www.pombase.org), the model organism database (MOD) for fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the Global Biodata Coalition (GBC; https://globalbiodata.org/) after a rigorous selection process. In this MOD review, we present PomBase's continuing growth and improvement over the last 2 years. We describe these improvements in the context of the qualitative GCBR indicators related to scientific quality, comprehensivity, accelerating science, user stories, and collaborations with other biodata resources. This review also showcases the depth of existing connections both within the biocuration ecosystem and between PomBase and its user community.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11075564 | PMC |
http://dx.doi.org/10.1093/genetics/iyae007 | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou, 310058, P.R. China.
Mechanoresponsive molecular devices are capable of exhibiting dynamic responses to external mechanical stimuli, enabling applications in smart materials, nano-devices, and flexible electronics. However, energy conversion induced by mechanical stimuli requires efficient energy dissipation mechanisms. Traditional methods often involve bond breaking or incomplete energy release, which can lead to device failure during continuous operations.
View Article and Find Full Text PDFBioanalysis
September 2025
GSK, Precision Medicine Design Assurance, Stevenage, UK.
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use M10 guideline provides a global framework for bioanalytical method validation in studies intended for regulatory submission. While its structure ensures consistency and data reliability, the guideline also acknowledges that not all studies require the same level of validation. This paper examines where full compliance is essential and where scientific judgment allows for leaner, context-driven validation, such as in early-stage development, for additional matrices, metabolites, nonstandard biological matrices or studies intended for internal decision-making.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan.
Background: Automated cardiac MR segmentation enables accurate and reproducible ventricular function assessment in Tetralogy of Fallot (ToF), whereas manual segmentation remains time-consuming and variable.
Purpose: To evaluate the deep learning (DL)-based models for automatic left ventricle (LV), right ventricle (RV), and LV myocardium segmentation in ToF, compared with manual reference standard annotations.
Study Type: Retrospective.
Phytomedicine
August 2025
Cardiology Department, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. Electronic address:
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along with chronic inflammation; this leads to increased risk of heart disease and stroke, significantly impacting patients' health. Danxia Tiaoban Decoction (DXTB), a traditional Chinese medicine (TCM) formula, has demonstrated positive clinical effects in treating AS; however, its mechanisms of action remain unclear.
Objective: To explore the potential mechanisms of action of DXTB in treating AS through multi-omics integration and experimental validation.
World Neurosurg
September 2025
Department of Anaesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
Objective: The present study intends to conduct a comprehensive bibliometric analysis of the research pertaining to the treatment of vertebral artery stenosis, with the objective of elucidating the evolution and trends in therapeutic strategies.
Methods: A bibliometric analysis of publications spanning between January 1, 1980, and August 13, 2024, was conducted utilizing the Web of Science Core Collection database. The analysis and visualization of the data were performed using VOSviewer, CiteSpace, and R package "bibliometrix" software.