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http://dx.doi.org/10.1093/cid/ciae079 | DOI Listing |
Pol Merkur Lekarski
September 2025
FACULTY OF NURSING, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: To evaluate clinical applicability of immune mediator's interleukin-16, immunoglobulin E along with eosinophil count in diagnosing COVID-19 and determining its severity.
Patients And Methods: Materials and Methods: Cross-sectional case-control study was conducted at Al-Najaf General Hospital, Najaf, Iraq between March and August 2024. 120 participants: 60 confirmed COVID-19 cases and 60 healthy controls which matched cases in terms of age and sex.
Crit Care Sci
September 2025
Universitätsklinikum Carl Gustav Carus - Dresden, Sachsen, Germany.
The PROtective VEntilation (PROVE) Network is a globally-recognized collaborative research group dedicated to advancing research, education, and collaboration in the field of mechanical ventilation. Established to address critical questions in intraoperative and intensive care ventilation, the network focuses on improving outcomes for patients undergoing mechanical ventilation in diverse settings, including operating rooms, intensive care units, burn units, and resource-limited environments in low- and middle-income countries. The PROVE Network is committed to generating high-quality evidence through a comprehensive portfolio of investigations, including randomized clinical trials, observational research, and meta-analyses.
View Article and Find Full Text PDFPLoS One
September 2025
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.
Objectives: To describe the research principles and cohort characteristics of the multi-disciplinary Project HERCULES, an innovative model of safe high-volume outpatient eye-care service for patients with stable chronic eye diseases. Results and analyses of the workstreams within Project HERCULES will be reported elsewhere. The rationale was to improve eye-care capacity in the National Health Service (NHS) in England through the creation of technician-delivered monitoring in a large retail-unit in a London shopping-centre, with remote asynchronous review of results by clinicians (named Eye-Testing and Review through Asynchronous Clinic (Eye-TRAC)).
View Article and Find Full Text PDFPLOS Glob Public Health
September 2025
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
This paper sought to identify and describe the innovations and adaptations implemented to ensure delivery of Sexual and Reproductive Health services during the COVID-19 pandemic and the potential for enhancing SRH services in other settings or in future emergencies. We searched five databases including PubMed, EMBASE, Scopus, Cochrane Library, and CINAHL. The review was registered on Prospero (CRD42022329411).
View Article and Find Full Text PDFBioinformatics
September 2025
The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Motivation: Drug repositioning presents a streamlined and cost-efficient way to expand the range of therapeutic possibilities. Drugs with human genetic evidence are more likely to advance successfully through clinical trials towards FDA approval. Single gene-based drug repositioning methods have been implemented, but approaches leveraging a broad spectrum of molecular signatures remain underexplored.
View Article and Find Full Text PDF