98%
921
2 minutes
20
Acquired cold-induced urticaria is a rare form of physical urticaria, especially in children. The variety of clinical presentations and the low estimated prevalence contribute to its underdiagnosis. Given the associated risk of anaphylaxis, it is crucial to alert clinicians to the different forms of presentation, diagnosis, and treatment. Starting with a case report of acquired cold-induced urticaria in a previously healthy nine-year-old boy, the authors then review the literature about acquired cold-induced urticaria and discuss the diagnostic exams and disease management.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869163 | PMC |
http://dx.doi.org/10.7759/cureus.52398 | DOI Listing |
Int Arch Allergy Immunol
August 2025
Introduction: Chronic spontaneous urticaria (CSU) presents as repetitive spontaneous hives and/or angioedema lasting for at least six weeks. In contrast, chronic inducible urticaria (CIndU) is triggered by specific stimuli. This study aimed to characterize children who have concurrent CSU and CIndU excluding children with symptomatic dermographism, and to identify factors that distinguish them from children with CSU alone or CIndU alone.
View Article and Find Full Text PDFFront Pediatr
August 2025
Department of Gastroenterology, Hepatology, and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Background: NLR family pyrin domain containing 3 (NLRP3)-associated autoinflammatory disease (NLRP3-AID), formerly known as cryopyrin-associated periodic syndrome, is a group of AIDs comprising neonatal-onset multisystem inflammatory disorder, Muckle-Wells syndrome, and familial cold autoinflammatory syndrome. Mutations in the NLRP3 gene are considered central to its pathogenesis.
Case Report: Here, we present a Chinese infant diagnosed with severe NLRP3-AID who carried a heterozygous variant in the NLRP3 gene.
Nat Immunol
September 2025
Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Understanding and treating inflammation has proven a formidable challenge. The initiator and central motor of inflammation, the protein NLRP3, is an innate immune sentinel and nonspecific sensor of cellular perturbation. A wide array of inflammatory triggers prompts the formation of an NLRP3 'inflammasome' complex, leading to inflammatory interleukin-1 family cytokine release and pyroptotic cell death.
View Article and Find Full Text PDFCurr Opin Allergy Clin Immunol
October 2025
Department of Precision and Regenerative Medicine and Ionian Area, Section of Allergology and Clinical Immunology, University Aldo Moro of Bari, Italy.
Purpose Of Review: This review provides an updated overview of the association between chronic urticaria (CU) and autoinflammatory syndromes (AS), underlining the diagnostic and therapeutic implications of identifying CU as an initial manifestation of systemic autoinflammatory disorders.
Recent Findings: emerging evidence has reinforced the role of innate immune dysregulation in the pathogenesis of CU associated with AS, with particular involvement of the pro-inflammatory cytokines such as interleukin (IL)-1β. Several monogenic and multifactorial autoinflammatory diseases, including cryopyrin-associated periodic syndromes (CAPS), Schnitzler syndrome (SchS), Still's disease (SD), and others, may present with CU.
J Allergy Clin Immunol Pract
July 2025
Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany. Electronic address
Background: A substantial subset of patients suffering from cold urticaria (ColdU) have atypical disease presentations and develop cold-induced wheals and/or angioedema in a real world setting but not in response to standard cold stimulation tests (CSTs). How to diagnose atypical ColdU is largely unclear, and little is known about the clinical features and treatment responses.
Objective: The aim of the study was to describe subtypes of atypical ColdU and provide recommendations for the diagnostic workup.