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Introduction: Snakebite envenomation poses a significant health risk, particularly in low-resource settings where access to proper treatment is limited.
Case Presentation: This study reports two cases of Russell's viper bites in rural Bangladesh, involving 48 and 35-year-old Bangladesh males, respectively, and highlights the difficulties in providing adequate medical care and in treating any complications that may arise. Both cases involved delayed access to healthcare, initial visit to traditional healers, and the development of severe complications such as coagulopathy, renal failure. After the intervention both cases survived which is scarce in low resource settings.
Conclusion: The cases underscore the importance of early recognition, appropriate management, and improved healthcare infrastructure to optimize survival outcomes in snakebite cases in resource-limited settings. These cases will contribute valuable insights to the field of snakebite management and provide guidance for improving survival rates and outcomes among snakebite victims in Bangladesh.
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http://dx.doi.org/10.1186/s13256-024-04354-0 | DOI Listing |
PLoS Negl Trop Dis
September 2025
Ocean and Fisheries Development International Cooperation Institute, College of Fisheries Science, Pukyong National University, Busan, Republic of Korea.
Background: Climate change is anticipated to significantly impact the biogeographic distribution of snakes, leading to notable shifts in their habitats toward anthropogenic landscapes. This may potentially increase the incidence of Big Four species (Bungarus caeruleus, Daboia russelii, Echis carinatus, and Naja naja) envenomation, a notable human-health risk that has not yet been assessed in India being the most affected country in South Asia. Therefore, this study integrates species distributions with socioeconomic and healthcare data to prioritize areas for targeted interventions to mitigate the envenomation risks effectively in India.
View Article and Find Full Text PDFClin Toxicol (Phila)
September 2025
South Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
Introduction: Early diagnosis of systemic snake envenoming is essential for prompt antivenom treatment. The commonly used 20-min whole blood clotting test has poor sensitivity. We investigated the diagnostic utility of non-specific systemic symptoms alone or with the 20-min whole blood clotting test in detecting Russell's viper () envenoming following a snakebite.
View Article and Find Full Text PDFToxins (Basel)
August 2025
Adaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Venoms of the Palearctic vipers in the genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five venoms-, , (Turkmenistan and Uzbekistan localities), and -using plasma clotting assays, Factors VII, X, XI, and XII and prothrombin zymogen activation assays, and SDS-PAGE to visualise Factor V (FV) cleavage. All venoms induced extremely rapid clot formation (10.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
November 2025
Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India. Electronic address:
Preclinical efficacy testing is an essential aspect of evaluating quality of antivenoms (AVs). Recent years have witnessed a surge in development of in vitro methods to replace or reduce reliance on the standard mouse lethality assay. In this study, we propose a novel, reversed phase liquid chromatography-mass spectrometry (RPLC-MS)-based platform for monitoring AV activity on venom components under the WHO recommended in solution AV testing conditions.
View Article and Find Full Text PDFJ Thromb Haemost
August 2025
Department of Hematology, Singapore General Hospital, Singapore.