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The authors describe the clinical, histologic, and serologic findings of a patient with necrotizing myositis of the extraocular muscles in the setting of antisynthetase syndrome, as well as subsequent management. This is the first case in the literature of a systemic necrotizing myositis to have associated ophthalmic findings.
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http://dx.doi.org/10.1097/IOP.0000000000002628 | DOI Listing |
Dan Med J
August 2025
Department of Regional Health Research, University of Southern Denmark.
Introduction: Erysipelas is a common disease in the emergency department, whereas necrotising soft tissue infections (NSTIs) are rare but more severe. The study aimed to investigate the prevalence, incidence, population-based incidence rate, one-year mortality and clinical presentation of erysipelas and NSTIs, and the aetiology, treatment and recurrence of erysipelas.
Methods: This was a population-based cohort study including acute non-trauma patients ≥ 18 years old with erysipelas or NSTIs from the Region of Southern Denmark in the period from 1 January 2016 to 19 March 2018.
Infect Drug Resist
September 2025
Department of Emergency Medicine, Affiliated Lu'an Hospital of Anhui Medical University, Lu'an, Anhui, 237005, People's Republic of China.
Hypervirulent is a recently identified pathotype characterized by high virulence and rapid dissemination. It is associated with invasive infections at multiple anatomical sites, including liver abscesses, necrotizing fasciitis, meningitis, myositis, and endophthalmitis. It has emerged as a significant threat to public health due to its aggressive clinical course and high mortality rate.
View Article and Find Full Text PDFBiomed Pharmacother
September 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Immune-mediated necrotizing myopathy (IMNM) is an emerging and severe form of myositis. Most patients experience persistent muscle weakness or recurrent attacks within their lifetime. The previous view suggests that autoimmune and complement activation play a key role in muscle damage, and aggressive immunotherapy may benefit patients.
View Article and Find Full Text PDFQJM
September 2025
Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel.
J Craniofac Surg
September 2025
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta.
Purpose: To demonstrate the use of negative pressure wound therapy (NPWT) and other reconstructive techniques in the reconstruction of large tissue defects resulting from periocular necrotizing fasciitis (NF).
Methods: Description of technique with 3 illustrative cases and accompanying photographic montage.
Results: Technique: Debridement successfully spared post-septal tissues and the lid margin in all cases.