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Unsupervised representation learning (URL) that learns compact embeddings of high-dimensional data without supervision has achieved remarkable progress recently. However, the development of URLs for different requirements is independent, which limits the generalization of the algorithms, especially prohibitive as the number of tasks grows. For example, dimension reduction (DR) methods, t-SNE and UMAP, optimize pairwise data relationships by preserving the global geometric structure, while self-supervised learning, SimCLR and BYOL, focuses on mining the local statistics of instances under specific augmentations. To address this dilemma, we summarize and propose a unified similarity-based URL framework, GenURL, which can adapt to various URL tasks smoothly. In this article, we regard URL tasks as different implicit constraints on the data geometric structure that help to seek optimal low-dimensional representations that boil down to data structural modeling (DSM) and low-dimensional transformation (LDT). Specifically, DSM provides a structure-based submodule to describe the global structures, and LDT learns compact low-dimensional embeddings with given pretext tasks. Moreover, an objective function, general Kullback-Leibler (GKL) divergence, is proposed to connect DSM and LDT naturally. Comprehensive experiments demonstrate that GenURL achieves consistent state-of-the-art performance in self-supervised visual learning, unsupervised knowledge distillation (KD), graph embeddings (GEs), and DR.
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http://dx.doi.org/10.1109/TNNLS.2023.3332087 | DOI Listing |
Med Phys
September 2025
School of Computer, Electronics and Information, Guangxi University, Nanning, China.
Background: Deformable medical image registration is a critical task in medical imaging-assisted diagnosis and treatment. In recent years, medical image registration methods based on deep learning have made significant success by leveraging prior knowledge, and the registration accuracy and computational efficiency have been greatly improved. Models based on Transformers have achieved better performance than convolutional neural network methods (ConvNet) in image registration.
View Article and Find Full Text PDFGenome Med
September 2025
School of Biomedical Engineering, Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
Background: Accurate subtyping and risk stratification are imperative for prognostication and clinical decision-making in small cell lung cancer (SCLC). However, traditional molecular subtyping is resource-intensive and challenging to translate into clinical practice.
Methods: A total of 517 SCLC patients and their corresponding hematoxylin and eosin (H&E)-stained whole slide images (WSIs) from three independent medical institutions were analyzed.
IEEE Trans Biomed Eng
September 2025
Objective: Quantitative susceptibility mapping (QSM) is a useful magnetic resonance imaging technique. We aim to propose a deep learning (DL)-based method for QSM reconstruction that is robust to data perturbations.
Methods: We developed Diffusion-QSM, a diffusion model-based method with a time-travel and resampling refinement module for high-quality QSM reconstruction.
Sci Rep
September 2025
Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 153-8902, Japan.
Recent studies have revealed that human emotions exhibit a high-dimensional, complex structure. A full capturing of this complexity requires new approaches, as conventional models that disregard high dimensionality risk overlooking key nuances of human emotions. Here, we examined the extent to which the latest generation of rapidly evolving Multimodal Large Language Models (MLLMs) capture these high-dimensional, intricate emotion structures, including capabilities and limitations.
View Article and Find Full Text PDFEntropy (Basel)
August 2025
School of Mathematics and Computer Application, Shangluo University, Shangluo 726000, China.
Unsupervised feature selection aims to characterize the cluster structure of original features and select the optimal subset without label guidance. However, existing methods overlook fuzzy information in the data, failing to model cluster structures between data effectively, and rely on squared error for data reconstruction, exacerbating noise impact. Therefore, a robust unsupervised feature selection algorithm based on fuzzy anchor graphs (FWFGFS) is proposed.
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