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Field-driven transport systems offer great promise for use as biofunctionalized carriers in microrobotics, biomedicine, and cell delivery applications. Despite the construction of artificial microtubules using several micromagnets, which provide a promising transport pathway for the synchronous delivery of microrobotic carriers to the targeted location inside microvascular networks, the selective transport of different microrobotic carriers remains an unexplored challenge. This study demonstrated the selective manipulation and transport of microrobotics along a patterned micromagnet using applied magnetic fields. Owing to varied field strengths, the magnetic beads used as the microrobotic carriers with different sizes revealed varied locomotion, including all of them moving along the same direction, selective rotation, bidirectional locomotion, and all of them moving in a reversed direction. Furthermore, cells immobilized with magnetic beads and nanoparticles also revealed varied locomotion. It is expected that such steering strategies of microrobotic carriers can be used in microvascular channels for the targeted delivery of drugs or cells in an organized manner.
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http://dx.doi.org/10.1002/smtd.202301495 | DOI Listing |
Adv Sci (Weinh)
August 2025
Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen, 361006, China.
Conventional thrombolytic agents demonstrated limited efficacy in treating thrombotic disorders characterized by narrow therapeutic windows and progressive vascular injury, lacking the required precision, timeliness, and treatment durability. Here an engineered probiotic powered micro-rod robot for targeted and penetrative treatment for thrombus is developed. This micro-rod robot (EcN) using natural probiotics as bio-carriers, functionalized with thrombolytic carbon nanotubes and platelet membrane-coated nanoparticles loaded with targeted vasodilators.
View Article and Find Full Text PDFACS Appl Bio Mater
August 2025
Maternal and Child Healthcare Medical Research Institute, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China.
Cell therapy has emerged as a highly effective treatment for degenerative diseases in recent years, and micro/nanorobots, with their small size and versatile mobility, have proven to be reliable carriers for active, targeted cell delivery. However, conventional cell delivery strategies rely on preseeded cells on the micro/nanorobots' surfaces, with in situ retention and subsequent release usually achieved by self-degradation of the carrier robots, which greatly limits their applicability and brings additional biosafety concerns. In this study, we propose an innovative approach to control cell capture and release by a microrobot using host-guest supramolecular interactions between azobenzene and β-cyclodextrin.
View Article and Find Full Text PDFMater Today Bio
August 2025
Engineering Research Center of Bio-Process, Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230009, People's Republic of China.
Traditional drug delivery systems are constrained by limitations such as low drug-loading efficiency, immunogenicity, and functional simplicity, rendering them inadequate to address the demands of complex pathological scenarios. Microalgae have emerged as a promising alternative system, possessing not only health benefits derived from their bioactive compounds but also inherent properties that naturally align with delivery system requirements. These advantageous characteristics include exceptional biocompatibility, easily modifiable surface properties, and photosynthetic oxygen-generating capacity.
View Article and Find Full Text PDFSci Adv
July 2025
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Confined spaces in the human body pose substantial challenges for biomedical procedures. Navigating these ultrasmall environments is essential for precise drug delivery, improving treatment outcomes and reducing adverse effects. Microrobots offer a promising approach to accessing these complex microenvironments.
View Article and Find Full Text PDFACS Appl Mater Interfaces
June 2025
The State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, Harbin 150080, PR China.
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodium alginate hydrogel magnetic robots as mitomycin drug carriers. The magnetic-driven hydrogel robots with mitomycin (MHRMs) are fabricated by uniformly mixing alginate solution, neodymium-iron-boron nanoparticles, and mitomycin, followed by the formation of MHRMs capable of carrying mitomycin in a calcium chloride solution.
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