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Abbreviated liver magnetic resonance imaging with a second-shot arterial phase image to assess the viability of treated hepatocellular carcinoma after non-radiation locoregional therapy.
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Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Purpose: To evaluate the feasibility of abbreviated liver magnetic resonance imaging (AMRI) with a second-shot arterial phase (SSAP) image for the viability of treated hepatocellular carcinoma (HCC) after non-radiation locoregional therapy (LRT).
Methods: We retrospectively enrolled patients with non-radiation LRT for HCC who underwent the modified gadoxetic acid-enhanced liver MRI protocol, which includes routine dynamic and SSAP imaging after the first and second injection of gadoxetic acid, respectively (6 mL and 4 mL, respectively), and an available reference standard for tumor viability in the treated HCC between March 2021 and February 2022. Two radiologists independently reviewed the full-protocol MRI (FP-MRI) and AMRI with SSAP.
Generalized Taylor dispersion of chiral microswimmers.
Philos Trans A Math Phys Eng Sci
September 2025
Research Institute for Mathematical Sciences, Kyoto University, Kyoto, Japan.
Transport phenomena of microswimmers in fluid flows play a crucial role in various biological processes, including bioconvection and cell sorting. In this article, we investigate the dispersion behaviour of chiral microswimmers in a simple shear flow using the generalized Taylor dispersion theory, inspired by biased locomotion of bacterial rheotaxis swimmers. We thus focused on the influence of shear-induced torque effects due to particle chirality, employing an extended Jeffery equation for individual deterministic dynamics.
View Article and Find Full Text PDFImproving magnetic field homogeneity in prostate MR imaging and spectroscopy using an add-on local external shim coil array.
MAGMA
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Department of Medical Imaging, (766), Radboud University Medical Center, Geert Grooteplein 10Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands.
Objective: To improve B field homogeneity in prostate MR imaging and spectroscopy using a custom-designed 16-channel external local shim coil array.
Methods: In vivo prostate imaging was performed in seven healthy volunteers (mean age: 40.7 years) without bowel preparation.
Balanced biocompatibility in high-viscosity hydroxypropyl methylcellulose-based sponge containing nanoconfined silver citrate nanoparticles.
Int J Biol Macromol
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Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, PR China. Electronic address:
Balancing antibacterial efficacy, mechanical integrity, and biocompatibility remains a critical challenge in drug release systems for wound dressings. Many antimicrobial agents exhibit inherent cytotoxicity, compromising cell viability and tissue compatibility. To address this, an Absorbable Gelatine Sponge was synthetised based on high-viscosity hydroxypropyl methylcellulose (HPMC K100M) and loaded with silver citrate nanorods (AgCit), which confine silver nanoparticles to enable controlled ion release.
View Article and Find Full Text PDFValidation of Cure Assumptions when Analyzing ZUMA-7 Follow-up Data of Axicabtagene Ciloleucel and Standard of Care Therapy in Second-Line Relapsed/Refractory Large B-cell Lymphoma.
Transplant Cell Ther
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H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Background: ZUMA-7 is the largest randomized controlled trial (RCT) for chimeric antigen receptor (CAR) T-cell therapy, which compared axicabtagene ciloleucel (axi-cel) to historical standard of care (HSoC) for the treatment of relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL). Both arms of ZUMA-7 contained potentially curative treatments; however, differences in the treatment completion rate and timing to receive definitive treatment led to differences in the extent and timing of cure. Mixture cure modeling (MCM) has been suggested as a superior method in designing and powering clinical studies of curative therapies but also for extrapolation of long-term outcomes in simulation studies.
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