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There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.
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http://dx.doi.org/10.1039/d3ay01995k | DOI Listing |
Anal Chim Acta
November 2025
State Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Detection of Veterinary Drug Residues and Illegal Additives of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address: haiyang
Background: Aflatoxin B1 (AFB1) stands among the most toxic naturally occurring substances, with its acute toxicity characterized by the induction of acute hepatic necrosis, hemorrhage, and even fatal outcomes, thereby posing a profound threat to human health. Contamination of AFB1 in food commodities can arise at multiple stages throughout the production cycle, including cultivation, storage, and processing. This contamination cascade permeates the entire food supply chain, encompassing primary agricultural products as well as a diverse range of processed food items.
View Article and Find Full Text PDFInt J Pharm
September 2025
Department of Pharmaceutics and Biopharmaceutics, Kiel University, Kiel, Germany. Electronic address:
Indomethacin is a poorly soluble weak acid and a widely used model drug in enabling formulations. When using microdialysis for sampling of indomethacin from a buffer containing calcium, we observed the formation of nanoparticles of a poorly water-soluble indomethacin calcium salt. The nanoparticles were not detected during solubility experiments where filtration had been used to separate the solid phase because the nanoparticles were unusually small in size, less than 2 nm in diameter as determined by DLS.
View Article and Find Full Text PDFEur J Pharm Biopharm
September 2025
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, PR China. Electronic address:
Iguratimod (IGU) is a novel anti-rheumatic drug, which has anti-inflammatory effects, inhibits bone destruction, and promotes bone formation. However, the gastrointestinal side-effects caused by oral tablets of IGU pose a challenge. This study aimed to develop an IGU transdermal patch for Rheumatoid Arthritis (RA) through ion-pair and chemical penetrant strategies to improve the therapeutic efficacy.
View Article and Find Full Text PDFExpert Opin Drug Deliv
September 2025
Department of Pharmacology, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India.
Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically successful targeted delivery of nanomedicines, it is crucial to understand why well-designed nanomedicines often fail during clinical trials.
Areas Covered: This review comprehensively explores the multifactorial reasons behind the poor clinical success rate of nanomedicines, including pathophysiological complexity, limitations in statistical analysis, inadequate animal models, variability in the EPR effect, and manufacturing challenges.
J Biomater Sci Polym Ed
September 2025
Department. of Pharmaceutics, Delhi Pharma Sciences and Research University (DPSRU)Govt of NCT of Delhi, New Delhi, India.
Chronic wounds infected with multidrug-resistant bacteria pose a significant therapeutic challenge, requiring biocompatible and effective interventions. This study presents a novel lignin-based nanoparticle spray for the localized delivery of curcumin, a natural anti-inflammatory and antimicrobial compound. Lignin, a sustainable polyphenolic biopolymer with inherent antioxidant and antimicrobial activities, was used both as a carrier and functional agent.
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