Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d3ay01995kDOI Listing

Publication Analysis

Top Keywords

drug permeation
12
setup screening
4
screening drug
4
permeation nmr
4
nmr spectroscopy
4
spectroscopy commercially
4
commercially setups
4
setups studying
4
studying drug
4
permeation differ
4

Similar Publications

Novel ultrafine Pt@Fe-MIL-101 nanozyme enables robust aflatoxin B1 immunoassay in diverse marine and agricultural systems.

Anal Chim Acta

November 2025

State Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Detection of Veterinary Drug Residues and Illegal Additives of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address: haiyang

Background: Aflatoxin B1 (AFB1) stands among the most toxic naturally occurring substances, with its acute toxicity characterized by the induction of acute hepatic necrosis, hemorrhage, and even fatal outcomes, thereby posing a profound threat to human health. Contamination of AFB1 in food commodities can arise at multiple stages throughout the production cycle, including cultivation, storage, and processing. This contamination cascade permeates the entire food supply chain, encompassing primary agricultural products as well as a diverse range of processed food items.

View Article and Find Full Text PDF

Indomethacin is a poorly soluble weak acid and a widely used model drug in enabling formulations. When using microdialysis for sampling of indomethacin from a buffer containing calcium, we observed the formation of nanoparticles of a poorly water-soluble indomethacin calcium salt. The nanoparticles were not detected during solubility experiments where filtration had been used to separate the solid phase because the nanoparticles were unusually small in size, less than 2 nm in diameter as determined by DLS.

View Article and Find Full Text PDF

Effect of the combination of ion-pairs strategies and permeation enhancers on iguratimod transdermal patch against rheumatoid arthritis.

Eur J Pharm Biopharm

September 2025

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, PR China. Electronic address:

Iguratimod (IGU) is a novel anti-rheumatic drug, which has anti-inflammatory effects, inhibits bone destruction, and promotes bone formation. However, the gastrointestinal side-effects caused by oral tablets of IGU pose a challenge. This study aimed to develop an IGU transdermal patch for Rheumatoid Arthritis (RA) through ion-pair and chemical penetrant strategies to improve the therapeutic efficacy.

View Article and Find Full Text PDF

Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically successful targeted delivery of nanomedicines, it is crucial to understand why well-designed nanomedicines often fail during clinical trials.

Areas Covered: This review comprehensively explores the multifactorial reasons behind the poor clinical success rate of nanomedicines, including pathophysiological complexity, limitations in statistical analysis, inadequate animal models, variability in the EPR effect, and manufacturing challenges.

View Article and Find Full Text PDF

Chronic wounds infected with multidrug-resistant bacteria pose a significant therapeutic challenge, requiring biocompatible and effective interventions. This study presents a novel lignin-based nanoparticle spray for the localized delivery of curcumin, a natural anti-inflammatory and antimicrobial compound. Lignin, a sustainable polyphenolic biopolymer with inherent antioxidant and antimicrobial activities, was used both as a carrier and functional agent.

View Article and Find Full Text PDF