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http://dx.doi.org/10.1161/JAHA.123.030952 | DOI Listing |
SAR QSAR Environ Res
September 2025
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Evaluating the permeability of different molecular structures across the Caco-2 cell line is crucial for drug discovery and development. The present study primarily focuses on developing machine learning-based multiclass classification models for predicting the permeability of molecules across the Caco-2 cell line. However, the class imbalance in permeability datasets poses a significant challenge for developing predictive models in the case of multiclass analysis.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
School of Materials Science and Engineering, Changchun University of Science and Technology Changchun, 130022, Jilin, People's Republic of China.
The synergistic effect of various ions with optical properties is an important method to regulate the Er ion upconversion luminescence process. However, the energy processes between them are complicated and difficult to separate, and it is challenging to clarify the results of each process when multiple ions are co-doped. Herein, a series of NaYF:Er were synthesized by the low-temperature combustion method, and the luminescence color of Er ions was modulated by doping Yb ions and Tm ions.
View Article and Find Full Text PDFBr J Nurs
September 2025
Macmillan Palliative and End of Life Care Practice Educator and Specialist Nurse Practitioner, Northampton General Hospital.
For individuals with diabetes, maintaining optimal glycaemic control is essential to reduce the risk of long-term complications. However, as patients approach the end of life, the emphasis on tight glycaemic targets becomes less relevant. Instead, the primary goal shifts to maintaining blood glucose levels within a range that minimises the risk of hypoglycaemia and prevents symptomatic hyperglycaemia, thereby ensuring comfort and quality of life.
View Article and Find Full Text PDFElectromagn Biol Med
September 2025
Computer Science and Business Systems, Sri Krishna College of Engineering and Technology, Coimbatore, India.
Subject-independent emotion detection using EEG (Electroencephalography) using Vibrational Mode Decomposition and deep learning is made possible by the scarcity of labelled EEG datasets encompassing a variety of emotions. Labelled EEG data collection over a wide range of emotional states from a broad and varied population is challenging and resource-intensive. As a result, models trained on small or biased datasets may fail to generalize well to unknown individuals or emotional states, resulting in lower accuracy and robustness in real-world applications.
View Article and Find Full Text PDFJ Pineal Res
September 2025
School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Melatonin, a multifunctional signalling molecule in plants, has been increasingly recognized for its role in improving stress tolerance, regulating hormone signalling, and enhancing crop productivity. Exogenous melatonin application represents a promising strategy to enhance crop productivity under global agricultural challenges. This study aimed to investigate the physiological and molecular mechanisms by which melatonin improves yield in Brassica napus.
View Article and Find Full Text PDF