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Article Abstract
The bacterial wilt caused by seriously affects crop yield and safety and is difficult to control. Biological activity-guided screening led to the isolation of 11 phenolic compounds including three undescribed compounds (carnemycin H-I and stromemycin B) from the secondary metabolites of a marine-derived . One new compound is an unusual phenolic dimer. Their structures were elucidated by comprehensive spectroscopic data and -based configurational analysis. The antibacterial activities of the isolated compounds against were evaluated. Compound exhibited excellent inhibitory activity with an MIC value of 3 μg/mL, which was comparable to that of streptomycin sulfate. Additionally, significantly changed the morphology and inhibited the activity of succinate dehydrogenase (SDH) to interfere with the growth of . Molecular docking was conducted to clarify the potential mechanisms of compound with SDH. Further experiments demonstrated that could remarkably inhibit the occurrence of bacterial wilt on tomatoes.
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| http://dx.doi.org/10.1021/acs.jafc.3c07826 | DOI Listing |
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