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Background: Thyroid nodules are common lesions in benign and malignant thyroid diseases. More and more studies have been conducted on the feasibility of artificial intelligence (AI) in the detection, diagnosis, and evaluation of thyroid nodules. The aim of this study was to use bibliometric methods to analyze and predict the hot spots and frontiers of AI in thyroid nodules.
Methods: Articles on the application of artificial intelligence in thyroid nodules were retrieved from the Web of Science core collection database. A website (https://bibliometric.com/), VOSviewer and CiteSpace software were used for bibliometric analyses. The collaboration maps of countries and institutions were analyzed. The cluster and timeline view based on cocitation references and keywords citation bursts visualization map were generated.
Results: The study included 601 papers about AI in thyroid nodules. China contributed to more than half (52.41%) of these publications. The cluster view and timeline view of co-citation references were assembled into 9 clusters, "AI", "deep learning", "papillary thyroid carcinoma", "radiomics", "ultrasound image", "biomarkers", "medical image segmentation", "central lymph node metastasis (CLNM)", and "self-organizing auto-encoder". The "AI", "radiomics", "medical image segmentation", "deep learning", and "CLNM", emerging in the last 10 years and continuing until recent years.
Conclusion: An increasing number of scholars were devoted to this field. The potential future research hotspots include risk factor assessment and CLNM prediction of thyroid carcinoma based on radiomics and deep learning, automatic segmentation based on medical images (especially ultrasound images).
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http://dx.doi.org/10.2174/0118715303264254231117113456 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.
BMC Endocr Disord
September 2025
Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef City, 62514, Egypt.
Background: Thyroid nodules (TNs) are frequent and often benign. Accurately differentiating between benign and malignant nodules is crucial for proper management. This research aims to use ultrasonography to examine TNs and identify possible risk factors in order to improve patient outcomes and diagnostic accuracy.
View Article and Find Full Text PDFAm J Surg
September 2025
Department of Surgery, Queen Mary Hospital, the University of Hong Kong, Hong Kong. Electronic address:
Introduction: Evaluating indeterminate thyroid nodules(ITN) is challenging, especially without molecular tests. This study examines whether artificial intelligence (AI) assistance can improve ITN diagnostic accuracy and bridge expertise gaps in surgeon-performed ultrasound.
Methods: 134 ultrasound clips from 67 patients with ITN were reviewed by doctors of four levels: endocrine-surgery specialist, senior residents, junior residents, and medical student.
Virchows Arch
September 2025
Ningbo Clinical Pathology Diagnosis Center, #685 Huancheng North Road, Ningbo, Zhejiang, 315000, China.
The spindle cell variant of papillary thyroid carcinoma (PTC) is exceptionally rare and poses significant diagnostic challenges due to its morphological overlap with other spindle cell lesions of the thyroid. We report a novel case of spindle cell variant PTC in a 66-year-old woman presenting with a TI-RADS 4 thyroid nodule, initially classified as Bethesda III on fine-needle aspiration. Histopathological examination revealed a biphasic tumor composed predominantly of bland spindle cells arranged in solid sheets and fascicles, admixed with entrapped thyroid follicles.
View Article and Find Full Text PDFCureus
August 2025
General Surgery, Saqr Hospital, Emirates Health Services, Ras Al Khaimah, ARE.
Introduction: The widespread utilization of neck ultrasound (US) by family physicians for the investigation of non-specific neck symptoms, as well as by endocrinologists and general surgeons for symptomatic thyroid problems, has led to an increase in the detection of nonpalpable thyroid nodules. This presents challenges and dilemmas regarding the decision to perform fine-needle aspiration cytology (FNAC). The routine use of cytology is often considered unnecessary, costly, and inconvenient for patients.
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