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http://dx.doi.org/10.1053/j.gastro.2023.12.015 | DOI Listing |
Biomed Pharmacother
September 2025
Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Germany.
Chronic pain (CP) is a major health issue globally, affecting millions and resulting in a significant healthcare burden. Although amitriptyline is widely used to manage CP, its immunomodulatory effects during pain therapy, especially on T cell phenotypes, remain unclear. In this study, we explored how amitriptyline alters T cell phenotypes in CP patients.
View Article and Find Full Text PDFJ Clin Neurol
September 2025
Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
Background And Purpose: Polypharmacy is common in Parkinson's disease (PD). This includes appropriate medications for PD-related symptoms and comorbid conditions, but also potentially inappropriate medications (PIMs). We aimed to determine the prescribing trends of PIMs based on the 2019 Beers Criteria in Korean patients with PD.
View Article and Find Full Text PDFTrials
August 2025
Fundació Institut Universitari per a La Recerca a L'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de Les Corts Catalanes 587, Àtic, 08007, Barcelona, Spain.
Background: Migraine is a neurological disorder affecting approximately 12% of the population, more frequent in women, causing disability. Preventive treatment is recommended to prevent chronification and analgesics' abuse and to improve quality of life, but not all candidates receive it. Common preventive drugs include amitriptyline, flunarizine, propranolol, and topiramate.
View Article and Find Full Text PDFBMC Prim Care
August 2025
Centre for Academic Primary Care, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
Background: There is a complex relationship between pain and mood disorders, and interactions between opioids and antidepressants can affect the effectiveness and adverse effects of these medicines when taken together. However, little is known about the scale of co-prescription for these medicines.
Methods: We used routinely collected primary care data from the Clinical Practice Research Datalink to describe the extent of opioid and antidepressant co-prescribing in over 4.
Background: Postherpetic neuralgia (PHN) is a neuropathic pain and the most common complication of herpes zoster (HZ). Pharmacotherapy serves as the primary intervention for alleviating pain associated with PHN.
Methods: Electronic databases were systematically searched to identify randomized controlled trials (RCTs) evaluating pharmacotherapy for PHN.