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http://dx.doi.org/10.2196/54952 | DOI Listing |
Curr Alzheimer Res
September 2025
Department of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Introduction: The complement receptor 1 (CR1) gene is identified as the one closely associated with Alzheimer's disease (AD). However, there has been no exploration of the imaging alterations associated with the CR1 gene in AD patients of the Han population. The purpose of this study is to investigate the association between the rs6656401 mutation and neuroimaging variations in Han AD patients.
View Article and Find Full Text PDFTurk J Pharm Sci
September 2025
İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Türkiye.
Objectives: This study focused on synthesizing and characterizing novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety and evaluating their antimicrobial activity against several bacterial strains. The research aimed to identify key structural features that enhance antimicrobial efficacy through structure-activity relationship analysis and identify the minimum inhibitory concentration (MIC) of the most potent compounds to assess their potential for further development as antimicrobial agents.
Materials And Methods: Nine novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety were synthesized by reacting 1,2,4-triazole derivatives with thiosemicarbazide precursors, and the products were characterized using infrared spectroscopy, proton nuclear magnetic resonance (H-NMR), carbon-13 nuclear magnetic resonance (C-NMR) spectroscopy, and elemental analysis.
Semin Dial
September 2025
Department of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Background: In hyponatremic patients, concurrent dialysate flow during hemodialysis may be an ideal option to mitigate complications such as osmotic demyelination syndrome (ODS).
Methods: Present randomized controlled trial enrolled dialysis-requiring chronic kidney disease (CKD) and acute kidney injury (AKI) patients with serum sodium levels < 125 mEq/L during January 2020 over 16 months. Hemodynamically unstable patients, as well as those with a history of seizures and neurological conditions, were excluded.
Acad Radiol
September 2025
Department of Radiology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey (E.E.).
Purpose: This study aimed to evaluate the performance of ChatGPT (GPT-4o) in interpreting free-text breast magnetic resonance imaging (MRI) reports by assigning BI-RADS categories and recommending appropriate clinical management steps in the absence of explicitly stated BI-RADS classifications.
Methods: In this retrospective, single-center study, a total of 352 documented full-text breast MRI reports of at least one identifiable breast lesion with descriptive imaging findings between January 2024 and June 2025 were included in the study. Incomplete reports due to technical limitations, reports describing only normal findings, and MRI examinations performed at external institutions were excluded from the study.