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http://dx.doi.org/10.1186/s40001-023-01582-w | DOI Listing |
Hum Reprod Update
September 2025
Women's Health Research Collaborative, New York, NY, USA.
Background: Reproductive-age women with intrauterine adhesions (IUAs) following uterine surgery may be asymptomatic or may experience light or absent menstruation, infertility, preterm delivery, and/or peripartum hemorrhage. Understanding procedure- and technique-specific risks and the available evidence on the impact of surgical adjuvants is essential to the design of future research.
Objective And Rationale: While many systematic reviews have been published, most deal with singular aspects of the problem.
Eur J Pharm Sci
September 2025
Department of Medicinal Chemistry, Uppsala University, SE-75123 Uppsala, Sweden. Electronic address:
Subcutaneous (SC) injection is the primary alternative to oral administration for therapeutic proteins and peptides. However, bioavailability and absorption rate are often variable and difficult to predict. Therefore, there is a need for new biorelevant and predictive SC in vitro methods.
View Article and Find Full Text PDFLancet Respir Med
September 2025
Effi-Stat, Paris, France.
Background: Among people with cystic fibrosis, sweat chloride and lung function response to elexacaftor-tezacaftor-ivacaftor (ETI) is variable. We hypothesised that the presence of two versus one ETI-responsive CFTR variant could predict response variability.
Methods: In this analysis of two real-world observational studies, data from a French national cohort of adults (aged ≥18 years) with cystic fibrosis and at least one F508del variant treated with ETI and the French compassionate programme for ETI in people (aged ≥6 years) with cystic fibrosis without F508del were used to examine sweat chloride concentrations (SCCs) after ETI initiation, and the absolute change in SCC and percentage of predicted forced expiratory volume in 1 s (ppFEV) following ETI initiation.
Adv Colloid Interface Sci
August 2025
Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Biotechnology and Physical Chemistry, Warszawska 24, 31-155 Cracow, Poland; Photo4Chem, Lea 114, 30-133 Cracow, Poland; Photo HiTech Ltd., Bobrzyskiego 14, 30-348 Cracow, Poland. Electronic address: joanna
Silatranization, a specialized variant of silanization using silatrane compounds, is emerging as a powerful strategy to functionalize material surfaces. Compared to conventional silane coupling agents, silatranes exhibit remarkable hydrolytic stability and enhanced resistance to self-condensation, enabling controllable, water-independent formation of a polysiloxane self-assembled monolayer. This review critically examines the unique structure of silatranyl cages, emphasizing how the intramolecular N->Si bond and chelate effect modulate the silicon center's reactivity toward hydroxyl-decorated surfaces.
View Article and Find Full Text PDFEarly Hum Dev
August 2025
Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China; Center for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China; National Health Commission (NHC) Key Lab
Objective: To synthesise current evidence on electroencephalography-based functional connectivity in preterm infants and clarify how prematurity alters early brain-network maturation.
Methods: A PRISMA-guided search (PubMed and Web of Science, inception-Mar 2025) identified 24 studies that quantified resting-state functional connectivity or graph-theory metrics in infants born <37 weeks' gestation. Study quality was rated with a six-item electroencephalography-functional connectivity checklist (reference montage, epoch length/number, artefact rejection, volume-conduction control, multiple-comparison correction).