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http://dx.doi.org/10.1016/j.pediatrneurol.2023.11.011 | DOI Listing |
Case Rep Psychiatry
August 2025
Department of Psychiatry and Behavioral Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
Delayed posthypoxic leukoencephalopathy (DPHL) is a rare diagnosis that may present similarly to other more common neurological conditions, such as catatonia. While often seen with carbon-monoxide poisoning, it can also be due to anoxia due to other causes, such as drug overdose or cardiac arrest. Due to the delayed nature of its symptoms and overlap with other conditions, it can be initially misdiagnosed.
View Article and Find Full Text PDFActa Neurochir (Wien)
July 2025
Neural Dynamics and Modulation Lab, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44196, USA.
In Mexico City, a 49-year-old man underwent strangulation, which led to hypoxic-ischemic encephalopathy (HIE) and subsequently to delayed post-hypoxic leukoencephalopathy (DPHL), a rare demyelinating condition. Following the attack, he exhibited aphasia, dysphagia, and other neuropsychiatric symptoms that progressed to dementia. Imaging and brain biopsy analyses disclosed extensive ischemic damage and reactive gliosis.
View Article and Find Full Text PDFClin Pract Cases Emerg Med
May 2025
University of Iowa Healthcare, Departments of Emergency and Internal Medicine, Iowa City, Iowa.
Introduction: Delayed post-hypoxic leukencephalopathy is a rare cause of acute neuropsychiatric decline diagnosable in the emergency department (ED), but it has not been described in the emergency medical literature. We present a case report of a pathognomonic presentation.
Case Report: A 53-year-old man developed akinetic mutism 14 days after being discharged from a hospitalization for fentanyl overdose.
Neurology
December 2024
From the Paris Brain Institute (G.V., E.A., P.B., V.N.), ICM, Inserm, CNRS, Sorbonne University; AP-HP (G.V., V.N.), EEG Unit, Department of Neurophysiology, Pitié-Salpêtrière Hospital; AP-HP (E.A.), Neurophysiology of Movement Disorders Unit, Department of Neurophysiology, Saint-Antoine and Piti
Background And Objectives: Lance-Adams syndrome (LAS), or chronic posthypoxic myoclonus, is a long-term disabling neurologic disorder occurring in survivors of anoxia. The cortical or subcortical origin of this myoclonus is unclear. We aimed to identify the neuroanatomical origin of myoclonus in LAS.
View Article and Find Full Text PDFIntern Med
June 2025
Department of Radiology, Jichi Medical University, Japan.