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Objective: The speech intelligibility index (SII) is used to quantify the audibility of the speech. This study examined the relationship between self-reported hearing aid (HA) outcomes and the difference in aided SII (SII) calculated from the initial fit (IF) gain and that prescribed as per the second generation of National Acoustic Laboratory Non-Linear (NAL-NL2).
Design: A prospective observational study.
Study Sample: The study included 718 first-time and 253 experienced HA users. All users had a valid real-ear measurement (REM) at three input levels (55, 65 and 80 dB SPL).
Results: The gain provided by IF was lower than NAL-NL2 at 55 and 65 dB SPL. IF gain exhibited reduced compression than NAL-NL2 as input levels increased from 55 to 80 dB SPL. On average, the SII provided by IF was significantly lower than that for NAL-NL2 at all input levels. The difference in SII between IF and NAL-NL2 at 80 dB SPL input level with 0 dB signal-to-noise ratio (SNR) turned out to be a predictor for self-reported outcome for first-time HA users.
Conclusion: The study suggests that an SIIA close to that provided by NAL-NL2 at high input levels would be preferred to obtain a better self-reported outcome. .
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http://dx.doi.org/10.1080/14992027.2023.2291633 | DOI Listing |
Front Microbiol
August 2025
Shanghai Kangshi Food Science and Technology Co., Ltd., Shanghai, China.
Unlabelled: Spices play a ubiquitous role in the food industry, imparting distinctive flavors and exhibiting antibacterial properties. Nonetheless, microbial contamination and residues present persistent challenges to food safety within this sector. The systematic tracking of microbial input datasets in spices holds significant guiding implications and economic value for microbial control and risk assessment in the food industry.
View Article and Find Full Text PDFFront Neural Circuits
September 2025
Faculty of Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.
Neuronal networks in animal brains are considered to realize specific filter functions through the precise configuration of synaptic weights, which are autonomously regulated without external supervision. In this study, we employ a single Hodgkin-Huxley-type neuron with autapses as a minimum model to computationally investigate how spike-timing-dependent plasticity (STDP) adjusts synaptic weights through recurrent feedback. The results show that the weights undergo oscillatory potentiation or depression with respect to autaptic delay and high-frequency stimulation.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Photo-responsive systems provide a powerful tool to reversibly regulate enzyme activity. However, inhibitor-based strategies, though widely used, are often restricted to specific enzymes. Noninhibitor strategies, such as enzyme surface modification or genetic mutation, often compromise structural integrity or residual activity.
View Article and Find Full Text PDFMetabolomics
September 2025
Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Introduction: Initially developed for transcriptomics data, pathway analysis (PA) methods can introduce biases when applied to metabolomics data, especially if input parameters are not chosen with care. This is particularly true for exometabolomics data, where there can be many metabolic steps between the measured exported metabolites in the profile and internal disruptions in the organism. However, evaluating PA methods experimentally is practically impossible when the sample's "true" metabolic disruption is unknown.
View Article and Find Full Text PDFMar Pollut Bull
September 2025
School of Marine Sciences, Sun Yat-sen University, and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China; The Research Center of Ocean Climate, Sun Yat-sen University, Zhuhai 519082, China; Pearl River Estuary Marine Ecosystem Research Station, Ministry of E
Estuarine plumes (EPs) are recognized as critical drivers of dissolved organic matter (DOM) heterogeneity in coastal zones, primarily by inducing phytoplankton blooms and subsequent bottom-water dissolved oxygen (DO) depletion. However, the specific mechanisms governing the EP-driven transformations of DOM molecular composition and biogeochemical fate remain elusive. Here, we integrated optical spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry to characterize the molecular signatures of DOM and their biogeochemical transformations within EP-influenced bottom waters of the Pearl River Estuary.
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