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Aims: First-generation closed-loop automated insulin delivery improves glycaemia and psychosocial outcomes among older adults with type 1 diabetes in clinical trials. However, no study has previously assessed real-world lived experience of older adults using closed-loop therapy outside a trial environment.
Methods: Semi-structured interviews were conducted with older adults who were pre-existing insulin pump users and previously completed the OldeR Adult Closed-Loop (ORACL) randomised trial. Interviews focused on perceptions of diabetes technology use, and factors influencing decisions regarding continuation.
Results: Twenty-eight participants, mean age 70 years (SD 5), were interviewed at median 650 days (IQR 608-694) after their final ORACL trial visit. At interview, 23 participants (82%) were still using a commercial closed-loop system (requiring manual input for prandial insulin bolus doses). Themes discussed in interviews relating to closed-loop system use included sustained psychosocial benefits, cost and retirement considerations and usability frustrations relating to sensor accuracy and system alarms. Of the five participants who had discontinued, reasons included cost, continuous glucose monitoring-associated difficulties and usability frustrations. Cost was the largest consideration regarding continued use; most participants considered the increased ease of diabetes management to be worth the associated costs, though cost was prohibitive for some.
Conclusions: Almost 2 years after completing a closed-loop clinical trial, closed-loop automated insulin delivery remains the preferred type 1 diabetes therapy for the majority of older adult participants. Chronological age is not a barrier to real-world successful use of diabetes technology. Identifying age-related barriers, and solutions, to diabetes technology use among older adults is warranted.
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http://dx.doi.org/10.1111/dme.15264 | DOI Listing |
Mult Scler Relat Disord
September 2025
Department of Psychology, Wayne State University, Detroit, MI, 48202, USA; Institute of Gerontology, Wayne State University, Detroit, MI, 48202, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI, 48201, USA. Electronic address:
The ability to navigate through one's environment is crucial for maintaining independence in daily life and depends on complex cognitive and motor functions that are vulnerable to decline in persons with Multiple Sclerosis (MS). While previous research suggests a role for mobility in the physical act of navigation, it remains unclear to what extent mobility impairment and perceptions of mobility constraints may modify wayfinding and the recall of environment details in support of successful navigation. Therefore, this study examined the relations among clinical mobility function, concern about falling, and recall of environment details in a clinical sample of MS.
View Article and Find Full Text PDFJ Biomech
August 2025
Lampe Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.
View Article and Find Full Text PDFJMIR Mhealth Uhealth
September 2025
Department of Neurology, School of Medicine, Washington University in St. Louis, 660 South Euclid Avenue, St Louis, MO, 63130, United States, 1 9548065162.
Background: Unsupervised cognitive assessments are becoming commonly used in studies of aging and neurodegenerative diseases. As assessments are completed in everyday environments and without a proctor, there are concerns about how common distractions may impact performance and whether these distractions may differentially impact those experiencing the earliest symptoms of dementia.
Objective: We examined the impact of self-reported interruptions, testing location, and social context during testing on remote cognitive assessments in older adults.
JMIR Cancer
September 2025
Department of Health Outcomes and Biomedical Informatics, University of Florida, 1889 Museum Road, Suite 7000, Gainesville, FL, 32611, United States, 1 352 294-5969.
Background: Disparities in cancer burden between transgender and cisgender individuals remain an underexplored area of research.
Objective: This study aimed to examine the cumulative incidence and associated risk factors for cancer and precancerous conditions among transgender individuals compared with matched cisgender individuals.
Methods: We conducted a retrospective cohort study using patient-level electronic health record (EHR) data from the University of Florida Health Integrated Data Repository between 2012 and 2023.
Cancer Nurs
September 2025
Author Affiliation: School of Nursing, University of Connecticut, Storrs.
Background: Breast cancer is a leading cause of cancer-related morbidity and mortality and imposes substantial financial strain on individuals and society. Minoritized groups, particularly Black/African American (AA) women, face a heightened risk of financial toxicity during treatment, even after accounting for socioeconomic differences.
Objective: The aim of this study was to explore and provide meaningful interpretations of the financial experiences of Black/AA breast cancer survivors (BCSs).