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Owing to the increasing market demand of Codonopsis Radix, the cropper blindly cultivates to expand planting area for economic benefits, which seriously affects the quality of Codonopsis Radix. Therefore, this study synthesized 207 batches of Codonopsis Radix and 115 ecological factors, and analyzed the suitable planting areas of Codonopsis pilosula under current and future climate change based on Geographic Information System (GIS) and MaxEnt model. Secondly, we evaluated the quality of Codonopsis Radix based on the all-in-one functional factor including chromatographic fingerprint, the index components, the effective compounds groups, the nutritional components, and the nutritional elements, and the quality regionalization of Codonopsis Radix was analyzed. Finally, the ecological factors affecting the accumulation of effective components of Codonopsis Radix were analyzed. This study found for the first time that the highly suitable area of Codonopsis pilosula was mainly distributed in the Weihe River system and the Bailongjiang River system in Gansu Province. There were differences in the quality of Codonopsis Radix from different ecologically suitable areas based on the all-in-one functional factors, and the comprehensive high-quality area of Codonopsis Radix was mainly distributed in Longnan and Longxi district of Gansu Province. The precipitation, temperature and altitude play a key role in the accumulation of chemical components in the 10 ecological factors affecting the distribution of Codonopsis pilosula. Under future climatic conditions, the highly suitable area of Codonopsis pilosula is decreased.
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http://dx.doi.org/10.1038/s41598-023-46546-6 | DOI Listing |
Biomed Chromatogr
October 2025
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Codonopsis Radix (CR) is widely used in the food and pharmaceutical industries. However, the existence of three botanical origins in CR makes it challenging to ensure the quality of CR in the market. In this study, a method was developed to identify and analyze CR from different botanical origins, and their signature components were quantitatively compared.
View Article and Find Full Text PDFFront Chem
July 2025
CQMPA Key Laboratory for Quality Control and Evaluation of Traditional Chinese Medicine, Chongqing Institute for Food and Drug Control, Chongqing, China.
Plant growth regulators (PGRs) enhance the biosynthesis of plant secondary metabolites but can cause environmental pollution and health risks, especially if synthetic or overused. Here, we developed a simple, high-throughput method using salting-out extraction and LC-MS/MS to analyze 62 PGR residues. The extraction, chromatographic conditions, and spectrometric parameters were systematically optimized.
View Article and Find Full Text PDFAnal Methods
July 2025
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Codonopsis Radix (CR), a traditional Chinese medicine with significant medicinal value, has been widely used for many years. In this study, a comprehensive quality evaluation system for CR from different regions was established using high-performance liquid chromatography (HPLC). First, the optimal extraction conditions for two glycoside components from CR were determined through response surface methodology, with the following parameters: a methanol ratio of 80%, an extraction time of 35 min, and a liquid-to-solid ratio of 50 : 1.
View Article and Find Full Text PDFJ Ethnopharmacol
July 2025
The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China; National Key Laboratory of Discovery and Utilization of Functional Components of Traditional Chinese M
Ethnopharmacological Relevance: Gastric ulcer (GU) is a prevalent gastrointestinal disease. Codonopsis Radix (CR), including three species of Codonopsis pilosula (Franch.) Nannf.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
National Center of Mass Spectrometry in Changchun & Jilin Provincial Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. Electronic address:
Ethnopharmacological Relevance: Codonopsis radix (CR), an herbal medicine, has been officially named and used since Wu Yiluo's "Bentushu Letter" in the Qing Dynasty. It has the effect of invigorating the spleen and lung, nourishing blood, and benefiting body fluid. However, there are few reports on the impact of CR on idiopathic pulmonary fibrosis (IPF).
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