Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Effect-directed analysis (EDA) combined with nontarget screening (NTS) has established a valuable tool for the identification of unmonitored toxic substances in environmental samples. It consists of three main steps: (1) highly potent fraction identification, (2) toxicant candidate selection, and (3) major toxicant identification. Here, we discuss the methodology, current status, limitations, and future challenges of EDA combined with NTS. This method has been applied successfully to various environmental samples, such as sediments, wastewater treatment plant effluents, and biota. We present several case studies and highlight key results. EDA has undergone significant technological advancements in the past 20 years, with the establishment of its key components: target chemical analysis, bioassays, fractionation, NTS, and data processing. However, it has not been incorporated widely into environmental monitoring programs. We provide suggestions for the application of EDA combined with NTS in environmental monitoring programs and management, with the identification of further research needs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702525 | PMC |
| http://dx.doi.org/10.1021/acs.est.3c05035 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multimodal insights into diverse pain experiences: PhysioPain dataset.
Data Brief
October 2025
Department of Computer Science and Engineering, College of Engineering, Qatar University, Doha, Qatar.
PhysioPain dataset comprises several physiological data of different kinds of pain: no pain, headache, menstrual cycle pain and back/neck/waist pain in search of a sophisticated and complete approach to pain representation. The study comprised 99 individuals, of whom 93 participants contributed real-time physiological data. These participants underwent experiment process to gather real-time physiological data including electroencephalogram (EEG), skin temperature, electrodermal activity (EDA), blood volume pulse (BVP), and accelerometer data.
View Article and Find Full Text PDFDetection of social anxiety using multiple simultaneous biosignals: A pilot study.
PLoS One
September 2025
University of Southampton, Electronics and Computer Science, Southampton, Hampshire, United Kingdom.
Social Anxiety Disorder (SAD) is a prevalent and debilitating condition characterized by heightened anxiety and avoidance behaviors in social situations. Despite the availability of treatment options, remission rates for SAD remain low, highlighting the need for more effective interventions. To support the development of more effective therapies, a better understanding of the psychophysiological mechanisms underlying SAD is needed.
View Article and Find Full Text PDFEmergency Preparedness and Response: Strategies for Mass Casualty Incidents.
Cureus
July 2025
Medicine, Hamdard University, Karachi, PAK.
This study presents a comprehensive retrospective analysis of 300 simulated mass casualty incidents (MCIs) in Pakistan from 2010 to 2024, aiming to evaluate emergency preparedness and response strategies. It is structured across four analytical domains: descriptive statistics, exploratory data analysis (EDA), inferential statistics, and predictive modeling. Findings reveal that terrorist attacks (n=115, 38.
View Article and Find Full Text PDFBovis calculus sativus improves cognitive function after ischemic stroke by regulating PKA/CREB/Sirt1/eIF2α signaling pathway.
J Ethnopharmacol
August 2025
School of Pharmaceutical Sciences, ZheJiang Chinese Medical University, Hangzhou, 310053, China. Electronic address:
Ethnopharmacological Relevance: Bovis calculus sativus (BCS) is a traditional medicinal agent known for its pharmacological properties, which include heat-clearing, mental faculty revitalization, liver-cooling, and anticonvulsant effects. It is widely used application in the treatment of ischemic stroke accompanied by cognitive impairment; however, further research is necessary to clarify its effects and underlying mechanisms.
Aim Of The Study: This study examined the therapeutic potential of BCS in mitigating ischemic stroke-induced cognitive impairment induced by ischemic stroke, focusing on its mechanism of action in enhancing synaptic plasticity via the PKA/CREB/Sirt1/eIF2α signaling pathway.
Successful Response to First-Line Carboplatin, Pemetrexed, and Bevacizumab for Peritoneal Mesothelioma: Two Case Reports.
Case Rep Oncol
January 2025
Department of Internal Medicine, Matsumoto Kyoritsu Hospital, Matsumoto, Japan.
Introduction: Peritoneal mesothelioma is an extremely rare malignancy of the peritoneum. It has a poor prognosis, and the optimal systemic chemotherapy remains controversial. Here, we report two cases of peritoneal mesothelioma with long-term survival and complete response to carboplatin, pemetrexed, and bevacizumab chemotherapy.
View Article and Find Full Text PDF