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Article Abstract
Two new prostaglandin-like compounds callicarboric acids A-B (1-2), along with six known compounds (3-8) were isolated from the stems of Callicarpa arborea Roxb. Their structures were determined with the help of modern spectroscopic techniques such as NMR, UV, IR, HR-ESI-MS, ECD, and ORD with the assistance of quantum chemical calculations. Compound 1 exhibited remarkable anti-NLRP3 inflammasome activation potential, demonstrating an IC value of 0.74 μM. Additionally, by reducing GSDMD-NT production, inhibiting caspase-1 activation, and suppressing IL-1β secretion, it effectively mitigated NLRP3 inflammasome-induced pyroptosis in J774A.1 cells. These findings indicate that compound 1 possesses the capability to be a valuable candidate for further research and development as an NLRP3 inflammasome inhibitor.
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Article Synopsis
- - Two new compounds, callicarboric acids A-B (1-2), were discovered in the stems of Callicarpa arborea, along with six already known compounds (3-8).
- - The structures of these compounds were analyzed using advanced techniques like NMR, UV, IR, and mass spectrometry, complemented by quantum chemical calculations.
- - Compound 1 showed strong potential as an NLRP3 inflammasome inhibitor, reducing harmful cell death and inflammation in specific cells, indicating it could be a promising candidate for additional research and development.
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