MGDUN: An interpretable network for multi-contrast MRI image super-resolution reconstruction.

Magnetic resonance imaging (MRI) Super-Resolution (SR) aims to obtain high resolution (HR) images with more detailed information for precise diagnosis and quantitative image analysis. Deep unfolding networks outperform general MRI SR reconstruction methods by providing better performance and improved interpretability, which enhance the trustworthiness required in clinical practice. Additionally, current SR reconstruction techniques often rely on a single contrast or a simple multi-contrast fusion mechanism, ignoring the complex relationships between different contrasts. To address these issues, in this paper, we propose a Model-Guided multi-contrast interpretable Deep Unfolding Network (MGDUN) for medical image SR reconstruction, which explicitly incorporates the well-studied multi-contrast MRI observation model into an unfolding iterative network. Specifically, we manually design an objective function for MGDUN that can be iteratively computed by the half-quadratic splitting algorithm. The iterative MGDUN algorithm is unfolded into a special model-guided deep unfolding network that explicitly takes into account both the multi-contrast relationship matrix and the MRI observation matrix during the end-to-end optimization process. Extensive experimental results on the multi-contrast IXI dataset and the BraTs 2019 dataset demonstrate the superiority of our proposed model, with PSNR reaching 37.3366 and 35.9690 respectively. Our proposed MGDUN provides a promising solution for multi-contrast MR image super-resolution reconstruction. Code is available at https://github.com/yggame/MGDUN.