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Background: Critical illness-associated cerebral microbleeds and leukoencephalopathy connected to coronavirus disease 2019 (COVID-19) infection are emerging areas of concern in current medical literature.
Methods: We reviewed cases of patients with COVID-19-associated neurological manifestations to study the prevalence and outcome of such conditions. Case Series Findings: Our review yielded seven distinct patients. Six exhibited cerebral microbleeds, primarily localized in the juxtacortical white matter and the corpus callosum. In contrast, one individual presented with leukoencephalopathy. Tragically, of these patients, five succumbed to their ailments. One was discharged with mild cognitive impairments, while another underwent a tracheostomy and was subsequently moved to a long-term care establishment.
Conclusion: Our findings underscore the significance of neuro-radiological observations in those grappling with severe manifestations of COVID-19, drawing attention to the possible neurological repercussions of the virus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618109 | PMC |
http://dx.doi.org/10.5339/qmj.2023.29 | DOI Listing |
Neuroscientist
September 2025
Department of Neurology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis.
View Article and Find Full Text PDFJ Am Heart Assoc
September 2025
KHP Centre for Translational Medicine, King's College London British Heart Foundation, Cardiovascular Division, Department of Clinical Pharmacology St Thomas' Hospital London United Kingdom.
Background: The aim of this study was to investigate the associations between pulse pressure (PP) and age-related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions, microbleeds, cerebral blood flow and metabolism, and beta-amyloid accumulation.
Methods: Systematic review of PubMed (MEDLINE), Scopus, and Ovid Embase (from inception to January 2023) and references of included studies among adult populations was conducted. Findings were summarized narratively and by performing a fixed-effects meta-analysis.
Int J Stroke
September 2025
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation.
Aims: This study investigated association of VCAM-1 and ICAM-1 with presence of CSVD and CSVD burden.
Neurol Genet
October 2025
Department of Neurology, National Taiwan University Hospital, Taipei.
Background And Objectives: Vascular NOTCH3 extracellular domain (NOTCH3ECD) deposition is the pathologic hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to explore the relationships among the NOTCH3ECD deposition load, the variant genotype, and cerebral small vessel disease (SVD) severity.
Methods: Fifty-four individuals carrying pathogenic variants were enrolled and underwent skin biopsy for the quantification of dermal vascular NOTCH3ECD deposition load using immunohistochemical staining.
Medicine (Baltimore)
August 2025
Department of Neurology, Shanghai Civil Aviation Hospital-Ruijin Hospital Gubei Branch, Shanghai, China.
Rationale: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy is a rare genetic condition classified as a cerebral small vessel disease (CSVD). Traditionally, this disorder has been linked to either homozygous or compound heterozygous mutations in the high-temperature requirement A serine peptidase 1 (HTRA1) gene. Nevertheless, contemporary research has uncovered that heterozygous mutations in HTRA1 can also manifest in patients displaying patterns of autosomal dominant inheritance.
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