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Bacteriophages are viruses that infect bacteria or archaea. Understanding the diverse and intricate genomic architectures of phages is essential to study microbial ecosystems and develop phage therapy strategies. However, the existing phage databases are short of meticulous annotations. To this end, we propose PhageScope (https://phagescope.deepomics.org), an online phage database with comprehensive annotations. PhageScope harbors a collection of 873 718 phage sequences from various sources. Applying fifteen state-of-the-art tools to perform systematic annotations and analyses, PhageScope provides annotations on genome completeness, host range, lifestyle information, taxonomy classification, nine types of structural and functional genetic elements, and three types of comparative genomic studies for curated phages. Additionally, PhageScope incorporates automatic analyses and visualizations for curated and customized phages, serving as an efficient platform for phage study.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767790 | PMC |
http://dx.doi.org/10.1093/nar/gkad979 | DOI Listing |
Neurotrauma Rep
August 2025
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Accurate differentiation between persistent vegetative state (PVS) and minimally conscious state and estimation of recovery likelihood in patients in PVS are crucial. This study analyzed electroencephalography (EEG) metrics to investigate their relationship with consciousness improvements in patients in PVS and developed a machine learning prediction model. We retrospectively evaluated 19 patients in PVS, categorizing them into two groups: those with improved consciousness ( = 7) and those without improvement ( = 12).
View Article and Find Full Text PDFNeuropsychology
September 2025
Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico.
Objective: Developmental dyslexia (DD) has been related to deficits in multiple cognitive skills. Phonological processing deficits are the most frequently reported in opaque orthographies, but there are few studies of transparent orthographies, such as Spanish. The aim of this study was to comprehensively explore possible deficiencies in cognitive functions in Spanish-speaking Mexican children with DD, to determine whether these deficits can explain problems with decoding fluency and accuracy, and analyze whether they provide support for some of the explanatory hypotheses of DD.
View Article and Find Full Text PDFFront Neurol
August 2025
McGovern Medical School, Department of Neurology, The University of Texas Health Houston, Houston, TX, United States.
Background: Recent trials of large core thrombectomy have shown that our traditional understanding of infarct characteristics and reperfusion benefit may be incomplete for patients with acute ischemic stroke (AIS). The Alberta Stroke Program Early CT Score (ASPECTS) has wide inter-rater variability, and modern studies have also shown that reperfusion therapies can benefit some patients regardless of the ASPECTS. Reproducible imaging metrics that account for the degree of hypo-attenuation on non-contrast computed tomography (NCCT) may be better suited to guide treatments.
View Article and Find Full Text PDFHistol Histopathol
September 2025
Institute of Pathology, University Hospital Bonn, Bonn, Germany.
Aims: We aimed to analyze CD63, a cell surface protein that has been associated with tumor aggressiveness in several cancers, including breast, colorectal, and lung cancer, as well as melanoma, in prostate cancer.
Methods: CD63 expression was analyzed immunohistochemically in a cohort of primary prostate cancers from 281 patients. The results were correlated with clinico-pathologic parameters, including biochemical recurrence.
Anal Chim Acta
November 2025
School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, PR China. Electronic address:
Even small deviations in modulation timing (DMT) can cause discrepancies between the originally set modulation period (P) and the actual P in comprehensive two-dimensional gas chromatography (GC × GC) analysis. This study explored the impact of DMT on the accuracy of the second dimensional retention time (t) and the second dimensional retention index (I) calculations and introduced a line detection technology (LDT) based on the Hough Transform to correct DMT-induced t shifts. The correction was achieved by automatically adjusting candidate P values until the slope of the line(s) (CB_line(s)) formed by column bleeding compound peaks in the isothermal section of the contour plot approached zero, thereby determining the actual P.
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