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With the rapid advancement of network communication and big data technologies, the Internet of Things (IoT) has permeated every facet of our lives. Meanwhile, the interconnected IoT devices have generated a substantial volume of data, which possess both economic and strategic value. However, owing to the inherently open nature of IoT environments and the limited capabilities and the distributed deployment of IoT devices, traditional access control methods fall short in addressing the challenges of secure IoT data management. On the one hand, the single point of failure issue is inevitable for the centralized access control schemes. On the other hand, most decentralized access control schemes still face problems such as token underutilization, the insecure distribution of user permissions, and inefficiency.This paper introduces a blockchain-based access control framework to address these challenges. Specifically, the proposed framework enables data owners to host their data and achieves user-defined lightweight data management. Additionally, through the strategic amalgamation of smart contracts and hash-chains, our access control scheme can limit the number of times (i.e., n-times access) a user can access the IoT data before the deadline. This also means that users can utilize their tokens multiple times (predefined by the data owner) within the deadline, thereby improving token utilization while ensuring strict access control. Furthermore, by leveraging the intrinsic characteristics of blockchain, our framework allows data owners to gain capabilities for auditing the access records of their data and verifying them. To empirically validate the effectiveness of our proposed framework and approach, we conducted extensive simulations, and the experimental results demonstrated the feasibility and efficiency of our solution.
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http://dx.doi.org/10.3390/s23208535 | DOI Listing |
Antimicrob Resist Infect Control
September 2025
School of Medicine and Health Management, Guizhou Province, Guizhou Medical University, GUI'an New District, 6 Ankang Avenue, Guiyang, People's Republic of China.
Background: Although current evidence supports the effectiveness of social norm feedback (SNF) interventions, their sustained integration into primary care remains limited. Drawing on the elements of the antimicrobial SNF intervention strategy identified through the Delphi-based evidence applicability evaluation, this study aims to explore the barriers and facilitators to its implementation in primary care institutions, thereby informing future optimization.
Methods: Based on the five domains of the Consolidated Framework for Implementation Research (CFIR), we developed semi-structured interview and focus group discussion guides.
Nat Med
September 2025
Emerging Technology, Research Prioritization and Support Unit, Department of Research for Health, World Health Organization, Geneva, Switzerland.
Clinical trials are essential to advancing cancer control, yet access and participation remain unequal globally. The World Health Organization (WHO) established the International Clinical Trials Registry Platform (ICTRP) to enable a complete view of interventional clinical research for all those involved in healthcare decision-making and to identify actionable goals to equitable participation at the global level. A review of 89,069 global cancer clinical trials registered in the WHO ICTRP between 1999 and December 2022 revealed a cancer clinical trial landscape dominated by high-income countries and focused on pharmacological interventions, with multinational collaboration limited to only 3% of recruiting trials.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Background: In the United States, cancer is more prevalent in racial and ethnic minority groups and in rural-dwelling and low-income people. Compared with White people of non-Hispanic descent, Black and African American people have higher cancer mortality and Hispanic people are more likely to be diagnosed with infection-related cancers. In addition, people who live in persistent poverty areas are more vulnerable to cancer mortality.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea.
Background: Autism spectrum disorder (ASD) and social communication disorder (SCD) are neurodevelopmental disorders characterized by deficits in social communication that hinder social adaptation, with limited pharmacological options for therapy owing to the absence of identified biomarkers. Individuals with ASD or SCD require lifelong interventions tailored to their development stages. However, most existing interventions primarily focus on early childhood, leaving adolescents relatively underserved.
View Article and Find Full Text PDFJ Control Release
September 2025
Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, 50411 Tartu, Estonia; Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA. Electronic address:
Most chemotherapeutics distribute non-specifically throughout the body, resulting in off-target toxicities. Nanoparticle (NP) formulations provide a strategy to improve drug delivery by extending circulation time, protecting therapeutic agents from degradation, and enabling controlled release. However, delivering NPs effectively to solid tumors remains challenging due to the barriers within the tumor microenvironment.
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