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http://dx.doi.org/10.5853/jos.2023.01753 | DOI Listing |
Metabolomics
September 2025
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Introduction: Knockout of the Fmo5 gene in mice led to a lean, slow-ageing phenotype characterised by the presence of 2,3-butanediol isomers in their urine and plasma. Oral treatment of wildtype mice with 2,3-butanediol led to a low cholesterol, low epididymal fat phenotype.
Objectives: Determine if significant, heterozygous coding variations in human FMO5 would give rise to similar clinical and metabolic phenotypes in humans, as in C57BL/6J mice with knockout of the Fmo5 gene and in particular, increased excretion of 2,3-butanediol.
J Anim Sci
September 2025
U.S. Meat Animal Research Center, USDA, ARS, Clay Center, NE 68933, USA.
Liver abscesses are a concern in feedlot cattle, and little is known about the role of genetics in their development. This study aimed to estimate genetic parameters and to identify single nucleotide polymorphisms (SNP) associated with liver abscesses. Crossbred cattle representing 18 breeds in the United States Meat Animal Research Center Germplasm Evaluation Program were phenotyped for liver abscesses at slaughter (n = 9,044).
View Article and Find Full Text PDFGeriatr Gerontol Int
September 2025
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Aim: The six-minute walk test (6MWT) allows patients to slow down, stop and rest as needed. However, the prognostic significance of 6MWT interruption remains unclear. Therefore, this study investigated the prognostic implications of 6MWT interruption in patients with heart failure (HF).
View Article and Find Full Text PDFFood Res Int
November 2025
School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:
The planetary health diet (PHD) proposed by the EAT-Lancet Commission, advocates for reduced meat and dairy intake while emphasizing the consumption of whole grains, fruits, vegetables, nuts, and legumes. Existing studies have shown that the PHD can lower mortality rates and slow cognitive decline in various populations. However, its specific effects on cognitive impairment among elderly individuals in China remain unclear, primarily due to regional socioeconomic and cultural differences.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China. Electronic address:
Food combinations featuring specific functional components represent one of the effective intervention strategies for alleviating functional gastrointestinal disorders induced by dietary and environmental factors. Honey and aloe vera have both been recognized as natural agents with laxative effects, yet the synergistic effects of their combination in alleviating constipation and the underlying regulatory mechanism remain to be elucidated. This study formulated a honey-aloe paste by employing honey as the primary ingredient compounded with aloe vera gel and investigated its preventive effects on loperamide-induced slow-transit constipation through a comprehensive analysis of gastrointestinal function and intestinal microenvironment.
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