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Background: Barriers at the system, clinician, and patient level limit access to medications for opioid use disorder (MOUD). The Advancing Pharmacological Treatments for Opioid Use Disorder (ADaPT-OUD) study implemented an external facilitation strategy within the Veterans Health Administration (VHA) aimed at facility-level barriers to improve uptake of MOUD. During ADaPT-OUD, an independent Academic Detailing Services Opioid Agonist Treatment of OUD Campaign was co-occurring and aimed to increase evidence-based practice for OUD at the clinician level. While both these initiatives aim to increase MOUD reach, they address different barriers and did not intentionally collaborate. Thus, understanding the interaction between these two independent implementation initiatives and their effect on MOUD reach will further inform and mold future implementation efforts of MOUD.
Methods: This was a secondary analysis of the ADaPT-OUD study that included 35 VHA facilities in the lowest quartile of MOUD reach; eight received the ADaPT-OUD external facilitation and 27 matched sites received implementation as usual. The number of academic detailing (AD) visits during ADaPT-OUD was used as a proxy for the intensity of Academic Detailing for OUD Campaign activity. The interaction between external facilitation status and AD intensity was evaluated by comparing the change in facility-level MOUD reach.
Results: There was a general increase in the number of AD visits, in both external facilitation and implementation as usual sites, over the course of ADaPT-OUD's implementation period. A non-statistically significant, positively sloped, linear relationship was observed between average number of AD visits per quarter and change in MOUD reach in facilities also receiving ADaPT-OUD external facilitation that was not observed in the implementation as usual sites.
Conclusion: Co-occurring initiatives focusing on different barriers to MOUD access have the potential to further increase MOUD in low-performing facilities, but further research into timing, quality, and collaboration between initiatives are warranted.
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http://dx.doi.org/10.1177/26334895231199463 | DOI Listing |
World J Pediatr
September 2025
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, China.
Background: Carbapenem-resistant Enterobacteriaceae (CRE) infections can pose a significant risk following pediatric liver transplantations. This study aimed to identify risk factors for CRE infections and develop prediction models for pediatric recipients.
Methods: This study enrolled pediatric patients who underwent liver transplantation between 2017 and 2023.
Abdom Radiol (NY)
September 2025
Johns Hopkins University, Baltimore, United States.
Vulvar anatomy and pathology can be a challenging subject to master, especially given the paucity of resources available on the subject. This review provides an overview of normal anatomy and imaging appearance of the vulva, including the mons pubis, labia majora, labia minora, clitoris, clitoral hood, external urethral meatus, vestibule and vaginal introitus, the Bartholin (greater vestibular) glands and the Skene (lesser vestibular or paraurethral) glands. We will also review the imaging appearance of various benign and malignant pathologies that affect these structures, including congenital adrenal hyperplasia, vulvar cancers, benign cysts, and urethral diverticula, with an emphasis on MR imaging.
View Article and Find Full Text PDFJ Orthop Res
September 2025
Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, Chaoyang District, China.
Injuries to the distal tibiofibular joint are often associated with ankle fractures, sports-related injuries, or instability, whereas proximal tibiofibular joint injuries are more commonly present with lateral- or posterolateral-compartment lesions of the knee. These conditions may be related to the relative motion between the tibia and fibula; however, precise movement patterns have yet to be fully elucidated. This study analyzes the relative motion of the tibia and fibula in 16 healthy adults (32 bones; 8 males and 8 females) throughout a normal gait cycle.
View Article and Find Full Text PDFClin Exp Ophthalmol
September 2025
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
Background: Reticular pseudodrusen (RPD) signify a critical phenotype driving vision loss in age-related macular degeneration (AMD). This study sought to develop and externally test a deep learning (DL) model to detect RPD on optical coherence tomography (OCT) scans with expert-level performance.
Methods: RPD were manually segmented in 9800 OCT B-scans from individuals enrolled in a multicentre randomised trial.
Langmuir
September 2025
Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Kamrup, Assam 781039, India.
The efficient and sustainable remediation of contaminated water calls for catalytic systems that must clean broadly, endure widely, and last repeatedly. In this regard, we report the development of sulfonate-functionalized core-shell hydrogel beads embedded with synthesized gold nanoparticles (AuNPs) that exhibit intrinsic oxidase-like activity without requiring external light or chemical oxidants. The sulfonate ligands modulate the surface electronic environment of the AuNPs, facilitating singlet oxygen generation via a nonplasmonic, radiationless mechanism.
View Article and Find Full Text PDF