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Cogan syndrome is a rare disease whose etiology is still undetermined. It typically affects men and women between the second and fourth decade of life. We report a case of Cogan syndrome with ocular and audio-vestibular involvement as a systemic manifestation in a 31-year-old woman.
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http://dx.doi.org/10.5693/djo.02.2023.07.001 | DOI Listing |
BMJ Case Rep
August 2025
Ophthalmology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
A woman in her 20 s with a remote history of chronic iritis and bilateral sensorineural hearing loss presented with proptosis, eye pain, blurred vision and elevated intraocular pressures. Her medical history was significant for end-stage renal disease and congestive heart failure. Imaging was limited due to cochlear implants and a cardioverter defibrillator.
View Article and Find Full Text PDFEpidemiologia (Basel)
August 2025
Third Department of Internal Medicine, General Hospital of Nikaia-Piraeus "Agios Panteleimon", 18454 Athens, Greece.
Aseptic abscess syndrome is a clinical entity that is being increasingly documented. Unfortunately, apart from the French registry, there are no other studies presenting collective data. In this review, we sought to analyze clinical and laboratory data from case reports published from the rest of the world.
View Article and Find Full Text PDFOxf Med Case Reports
August 2025
Adult and Pediatric Cardiac Surgery Department, Cardiac Innovation Center of Apollonion Private Hospital, Nicosia, Cyprus.
Cogan Syndrome (CS) is a rare autoimmune disease, complicated by a variety of cardiac manifestations. This case report represents the only documented case in the Republic of Cyprus. It describes the experience of a 23- year-old woman with CS who presented with newly diagnosed, severe aortic regurgitation (AR) and suspected endocarditis.
View Article and Find Full Text PDFAm J Med Genet A
August 2025
Department of Pediatrics, Division of Medical Genetics and Genomic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nizon-Isidor syndrome is a rare disorder caused by heterozygous variants in MED12L, with only eight documented cases in the literature. Here, we present three additional cases of this syndrome. Proband 1 was a 7-year-old female who presented with developmental delay, right-leg hemihypertrophy, laryngeal cleft, esotropia, abnormal skin pigmentation, sectoral iris hypopigmentation, dysphagia, periventricular nodular heterotopia, seizures, morbid obesity, and a pelvic kidney.
View Article and Find Full Text PDFOcul Immunol Inflamm
August 2025
Department of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Purpose: Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disorder characterized by concurrent renal and ocular inflammation. Auditory features resembling Cogan's syndrome have been reported in TINU, though the nature of this overlap remains poorly understood. Here, we report a pediatric case of atypical Cogan syndrome to contribute to the growing literature on this unusual clinical association.
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