Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers.

Purpose: The aim of this study was to describe corneal biomechanical changes in individuals carrying the p.Ala546Asp mutation, compare those with and without visible corneal deposits, and explore their potential relevance for early biomechanical characterization.

Methods: A case series was conducted in a Mexican mestizo family with confirmed molecular diagnosis of granular corneal dystrophy type 2 (GCD2).

Trends in Corneal Transplantation at a Mexican Ophthalmological Center: 12 Years of Experience.

Purpose: To analyze the trends and characteristics of eye banking and corneal transplantation over a 12-year period at an ophthalmological center in Mexico City.

Methods: We performed a retrospective, descriptive study including all patients who underwent corneal transplantation at a Mexican ophthalmology reference center between January 2011 and December 2022. Statistical analyses were conducted with data reported as complete counts or mean with standard deviations.

Indirect Corneal Neurotization: Long-Term Outcomes Using a Sural Nerve Graft in Patients With Facial Palsy and Neurotrophic Keratopathy.

Purpose: To report long-term clinical outcomes of patients with neurotrophic keratopathy and facial palsy secondary to neurosurgery treated with an indirect technique of corneal neurotization (CN) using a sural nerve graft.

Methods: A multicenter, prospective, interventional, noncontrolled study. Subjects underwent indirect CN as part of a staged procedure for reanimation of the affected half of the face using a sural nerve graft coapted to the supratrochlear nerve and nerve fascicles sutured subconjunctivally to the perilimbal region.

Surgical Considerations for the Human Implantation of the Gore Synthetic Corneal Device.

Purpose: To describe the surgical technique for implantation of a novel flexible, suturable, intrastromal synthetic cornea device.

Methods: This report is a description of a novel surgical technique. Adult patients (≥18 years) with corneal edema who met specific inclusion criteria were enrolled.

Rose bengal photodynamic antimicrobial therapy combined with amniotic membrane graft for the management of infectious keratitis in a patient with keratoprosthesis.

Purpose: To describe the use of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) combined with amniotic membrane graft (AMG) as a novel surgical technique for infectious keratitis in a patient with Boston Keratoprosthesis (B-Kpro) type 1 Lucia.

Methods: A 91-year-old woman with a history of B-Kpro type 1 Lucia implantation in both eyes presented for routine follow-up complaining of pain and redness in the left eye. Slit-lamp examination revealed a 6 mm corneal infiltrate with an epithelial defect adjacent to the optic stem.

Safety and Efficacy of a Mesenchymal Stem Cell Secretome Therapy (KPI-012) for Persistent Corneal Epithelial Defects: A Phase 1b Trial.

Background: Persistent corneal epithelial defect (PCED) is a condition often refractory to conventional treatments. KPI-012 is a topical mesenchymal stem cell secretome therapy under investigation for PCED management.

Objective: To assess the safety, tolerability, and corneal wound healing efficacy of KPI-012 in a phase 1b, proof-of-concept, open-label, single-arm clinical trial.

Stevens-Johnson Syndrome as a Risk Factor for Ocular Surface Squamous Neoplasia in a Pediatric Patient.

This report describes a rare case of ocular surface squamous neoplasia (OSSN) developing in the aftermath of Stevens-Johnson syndrome (SJS). A 15-year-old female patient, who had previously experienced an episode of SJS triggered by non-steroidal anti-inflammatory drugs (NSAIDs), developed limbal stem cell deficiency (LSCD) and was subsequently diagnosed with OSSN in the setting of chronic ocular surface inflammation. She was treated successfully with topical immunotherapy using interferon alpha-2b.

In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review.

Background: In vivo confocal microscopy (IVCM) is an advanced imaging technique that enables real-time, high-resolution visualization of corneal microstructures. Its clinical applications have expanded significantly, offering valuable insights into the pathophysiology of various ocular surface and corneal disorders. Despite its utility, challenges in standardization, accessibility, and integration into routine practice limit its widespread adoption.

Stapler for corneal transplantation: a hypothesis.

Background: Corneal transplantation requires exquisite microsurgical precision, particularly during the suturing of donor and recipient tissues. In corneal transplantation procedures such as penetrating keratoplasty, the donor cornea is traditionally secured using ultrafine 10-0 nylon sutures, meticulously placed under an operating microscope to achieve precise tension and promote optimal wound healing. Although this technique remains the reference standard, it is inherently time-intensive and requires advanced microsurgical expertise.

Superior Limbic Keratoconjunctivitis: Pathophysiology, Diagnosis, and Advances in Therapeutic Strategies.

Background: Superior limbic keratoconjunctivitis (SLK) is a chronic inflammatory disorder of the ocular surface, primarily affecting the superior bulbar and palpebral conjunctiva. It predominantly occurs in middle-aged women and is associated with conditions, such as dry eye disease, thyroid eye disease, and ocular graft-versus-host disease. Although its exact etiology remains unclear, mechanical microtrauma and tear film instability are key contributing factors.

Filamentary Keratitis: A Persistent Challenge in Ocular Surface Disease.

Purpose: To provide a comprehensive overview of filamentary keratitis (FK), its pathophysiology, associated conditions, clinical manifestations, and current management strategies.

Methods: A narrative review of the literature describing the etiopathogenesis, clinical features, and therapeutic approaches for FK. Emphasis was placed on conventional treatments, advanced medical therapies, and surgical interventions used in refractory cases.

Cyanoacrylate Glue Patch for Corneal Melting in Keratoprosthesis.

Purpose: To report clinical outcomes of cyanoacrylate glue patches in managing corneal melting in keratoprosthesis (KPro).

Methods: Multicenter, retrospective, noncontrolled, interventional case series. Subjects underwent cyanoacrylate glue patches for corneal melt after KPro implantation, regardless of the underlying cause, KPro design, or melt severity.

Postoperative Outcomes Regarding Tear Film Changes and Dry Eye Symptoms in Primary Pterygium Excision With Conjunctival Autograft.

Objective: To determine changes in tear film characteristics and dry eye symptoms in patients who underwent primary pterygium excision with conjunctival autograft.

Methods: A prospective, descriptive, analytic study was performed. Patients with primary pterygium who underwent surgical excision with conjunctival autograft were included.

Scleral Tattooing Complications: Surgical Management of Granulomas in a Cosmetic Procedure.

Purpose: To report the surgical management and outcomes of a patient with granulomatous inflammation following scleral tattooing, emphasizing the associated risks and clinical implications.

Methods: A 26-year-old woman with a history of multiple body modifications, including scleral tattooing, presented with bilateral ocular pain and discomfort. Clinical examination revealed corneal dellen and subconjunctival granulomas.

Ocular Rosacea: An Updated Review.

Purpose: Ocular rosacea is a chronic inflammatory disorder affecting the ocular surface, often associated with cutaneous rosacea. This review aims to explore its pathogenesis, treatment approaches, and future directions for management.

Methods: A review of current literature on the pathophysiology, clinical features, and treatment strategies of ocular rosacea in adults and children (pediatric blepharokeratoconjunctivitis) was conducted.

Lucia Keratoprosthesis in a Sclerocorneal Graft for Recurrent Graft Rejection Secondary to Herpetic Keratitis.

Purpose: To report the surgical approach of a Lucia keratoprosthesis (KPro) on a sclerocorneal graft in the setting of recurrent graft rejection and perilimbal scleral thinning.

Methods: A case report.

Results: We report the case of a 26-year-old man with a history of herpes simplex keratitis, 2 penetrating keratoplasties, graft failure, secondary glaucoma, and a conjunctival flap in the right eye who underwent a Lucia KPro, lens extraction, glaucoma drainage device, and pars plana vitrectomy.

Visual and refractive outcomes after SMILE versus FS-LASIK: a paired-eye study.

Objective: To compare visual acuity, refraction, Schirmer test, tear break-up time (TBUT), esthesiometry, optical quality, higher order aberrations and posterior corneal elevation measurements before and after small-incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK).

Method: Paired eye, randomized, cohort study. Follow-up was performed at days 1 and 7, and at months 1, 3, 6 and 12.

Effects of the COVID-19 Pandemic on Microbial Keratitis: A 5-Year Comparative Study.

Purpose: To report the clinical and microbiological profiles of microbial keratitis and its antimicrobial resistance before, during, and after COVID-19.

Methods: This was a retrospective case-note review of all corneal scrape specimens collected from patients with microbial keratitis from January 2018 to December 2023. Case records were analyzed for demographic characteristics, microbiological diagnosis, and antibiograms.

Corneal and Ocular Surface Contributions From Mexico: A Bibliometric Analysis From 1913 to 2022.

Objective: This study aimed to investigate all recorded corneal and ocular surface research by Mexican authors.

Methods: The output data was extracted from SCOPUS to account for all publications regarding the corneal or ocular surface by Mexican authors. Data screening, extraction, and critical revision were performed by two of the authors to avoid duplication and ensure the authenticity of all papers.

Giant corneal keloid following Descemet stripping automated endothelial keratoplasty for the treatment of corneal decompensation secondary to trauma.

Purpose: This report aims to present a case of corneal keloid caused by chronic corneal insult after trauma and Descemet stripping automated endothelial keratoplasty (DSAEK).

Case Presentation: A 35-year-old male with a history of vision loss in the right eye was referred to our hospital. The patient underwent Ahmed Glaucoma Valve Implantation to alleviate elevated intraocular pressure after ocular trauma to the same eye.

Results of Lucia Keratoprosthesis Implantation in Severe Corneal Disease.

Purpose: Describe complications, functional success, and retention of the Lucia Keratoprosthesis (KPro).

Design: Retrospective interventional case series METHODS: The demographic data, baseline characteristics, complications, functional success, and retention were analyzed for Lucia KPro at the Instituto de Oftalmologia Conde de Valenciana in Mexico City from 2021 to 2023. Multivariate regression analysis and Kaplan-Meier plots were performed to identify associations with functional failure.

Mitomycin Intravascular Chemoembolization for Corneal Neovascularization.

Purpose: The purpose of the study was to evaluate the efficacy of mitomycin C intravascular chemoembolization (MICE) for corneal neovascularization (CNV).

Methods: This is a prospective, nonrandomized, interventional study. Patients with stable CNV irrespective of the underlying etiology were enrolled in the study.