Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers.

Purpose: The aim of this study was to describe corneal biomechanical changes in individuals carrying the p.Ala546Asp mutation, compare those with and without visible corneal deposits, and explore their potential relevance for early biomechanical characterization.

Methods: A case series was conducted in a Mexican mestizo family with confirmed molecular diagnosis of granular corneal dystrophy type 2 (GCD2).

Trends in Corneal Transplantation at a Mexican Ophthalmological Center: 12 Years of Experience.

Purpose: To analyze the trends and characteristics of eye banking and corneal transplantation over a 12-year period at an ophthalmological center in Mexico City.

Methods: We performed a retrospective, descriptive study including all patients who underwent corneal transplantation at a Mexican ophthalmology reference center between January 2011 and December 2022. Statistical analyses were conducted with data reported as complete counts or mean with standard deviations.

Indirect Corneal Neurotization: Long-Term Outcomes Using a Sural Nerve Graft in Patients With Facial Palsy and Neurotrophic Keratopathy.

Purpose: To report long-term clinical outcomes of patients with neurotrophic keratopathy and facial palsy secondary to neurosurgery treated with an indirect technique of corneal neurotization (CN) using a sural nerve graft.

Methods: A multicenter, prospective, interventional, noncontrolled study. Subjects underwent indirect CN as part of a staged procedure for reanimation of the affected half of the face using a sural nerve graft coapted to the supratrochlear nerve and nerve fascicles sutured subconjunctivally to the perilimbal region.

Rose bengal photodynamic antimicrobial therapy combined with amniotic membrane graft for the management of infectious keratitis in a patient with keratoprosthesis.

Purpose: To describe the use of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) combined with amniotic membrane graft (AMG) as a novel surgical technique for infectious keratitis in a patient with Boston Keratoprosthesis (B-Kpro) type 1 Lucia.

Methods: A 91-year-old woman with a history of B-Kpro type 1 Lucia implantation in both eyes presented for routine follow-up complaining of pain and redness in the left eye. Slit-lamp examination revealed a 6 mm corneal infiltrate with an epithelial defect adjacent to the optic stem.

In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review.

Background: In vivo confocal microscopy (IVCM) is an advanced imaging technique that enables real-time, high-resolution visualization of corneal microstructures. Its clinical applications have expanded significantly, offering valuable insights into the pathophysiology of various ocular surface and corneal disorders. Despite its utility, challenges in standardization, accessibility, and integration into routine practice limit its widespread adoption.

Stapler for corneal transplantation: a hypothesis.

Background: Corneal transplantation requires exquisite microsurgical precision, particularly during the suturing of donor and recipient tissues. In corneal transplantation procedures such as penetrating keratoplasty, the donor cornea is traditionally secured using ultrafine 10-0 nylon sutures, meticulously placed under an operating microscope to achieve precise tension and promote optimal wound healing. Although this technique remains the reference standard, it is inherently time-intensive and requires advanced microsurgical expertise.

Superior Limbic Keratoconjunctivitis: Pathophysiology, Diagnosis, and Advances in Therapeutic Strategies.

Background: Superior limbic keratoconjunctivitis (SLK) is a chronic inflammatory disorder of the ocular surface, primarily affecting the superior bulbar and palpebral conjunctiva. It predominantly occurs in middle-aged women and is associated with conditions, such as dry eye disease, thyroid eye disease, and ocular graft-versus-host disease. Although its exact etiology remains unclear, mechanical microtrauma and tear film instability are key contributing factors.

Unveiling the complexity of Schimmelpenning-Feuerstein-Mims syndrome: A comprehensive case study.

Purpose: The purpose of this study was to report the comprehensively examined patient exhibiting oculocutaneous clinical features of Schimmelpenning-Feuerstein-Mims syndrome (SFMS).

Background: Schimmelpenning-Feuerstein-Mims syndrome (SFMS) is a rare phakomatosis characterized by the presence of sebaceous hamartomas on the skin along with extracutaneous abnormalities involving various neuroectodermal systems. The syndrome is typically sporadic and can originate from postzygotic mutations in genes implicated in the RAS signaling pathway (RAS proteins and their downstream pathways play pivotal roles in cell proliferation, differentiation, survival, and cell death): (11p15), (1p13), and (12p12).

Cyanoacrylate Glue Patch for Corneal Melting in Keratoprosthesis.

Purpose: To report clinical outcomes of cyanoacrylate glue patches in managing corneal melting in keratoprosthesis (KPro).

Methods: Multicenter, retrospective, noncontrolled, interventional case series. Subjects underwent cyanoacrylate glue patches for corneal melt after KPro implantation, regardless of the underlying cause, KPro design, or melt severity.

Postoperative Outcomes Regarding Tear Film Changes and Dry Eye Symptoms in Primary Pterygium Excision With Conjunctival Autograft.

Objective: To determine changes in tear film characteristics and dry eye symptoms in patients who underwent primary pterygium excision with conjunctival autograft.

Methods: A prospective, descriptive, analytic study was performed. Patients with primary pterygium who underwent surgical excision with conjunctival autograft were included.

Ocular Rosacea: An Updated Review.

Purpose: Ocular rosacea is a chronic inflammatory disorder affecting the ocular surface, often associated with cutaneous rosacea. This review aims to explore its pathogenesis, treatment approaches, and future directions for management.

Methods: A review of current literature on the pathophysiology, clinical features, and treatment strategies of ocular rosacea in adults and children (pediatric blepharokeratoconjunctivitis) was conducted.

Lucia Keratoprosthesis in a Sclerocorneal Graft for Recurrent Graft Rejection Secondary to Herpetic Keratitis.

Purpose: To report the surgical approach of a Lucia keratoprosthesis (KPro) on a sclerocorneal graft in the setting of recurrent graft rejection and perilimbal scleral thinning.

Methods: A case report.

Results: We report the case of a 26-year-old man with a history of herpes simplex keratitis, 2 penetrating keratoplasties, graft failure, secondary glaucoma, and a conjunctival flap in the right eye who underwent a Lucia KPro, lens extraction, glaucoma drainage device, and pars plana vitrectomy.

Effects of the COVID-19 Pandemic on Microbial Keratitis: A 5-Year Comparative Study.

Purpose: To report the clinical and microbiological profiles of microbial keratitis and its antimicrobial resistance before, during, and after COVID-19.

Methods: This was a retrospective case-note review of all corneal scrape specimens collected from patients with microbial keratitis from January 2018 to December 2023. Case records were analyzed for demographic characteristics, microbiological diagnosis, and antibiograms.

Corneal and Ocular Surface Contributions From Mexico: A Bibliometric Analysis From 1913 to 2022.

Objective: This study aimed to investigate all recorded corneal and ocular surface research by Mexican authors.

Methods: The output data was extracted from SCOPUS to account for all publications regarding the corneal or ocular surface by Mexican authors. Data screening, extraction, and critical revision were performed by two of the authors to avoid duplication and ensure the authenticity of all papers.

Giant corneal keloid following Descemet stripping automated endothelial keratoplasty for the treatment of corneal decompensation secondary to trauma.

Purpose: This report aims to present a case of corneal keloid caused by chronic corneal insult after trauma and Descemet stripping automated endothelial keratoplasty (DSAEK).

Case Presentation: A 35-year-old male with a history of vision loss in the right eye was referred to our hospital. The patient underwent Ahmed Glaucoma Valve Implantation to alleviate elevated intraocular pressure after ocular trauma to the same eye.

Results of Lucia Keratoprosthesis Implantation in Severe Corneal Disease.

Purpose: Describe complications, functional success, and retention of the Lucia Keratoprosthesis (KPro).

Design: Retrospective interventional case series METHODS: The demographic data, baseline characteristics, complications, functional success, and retention were analyzed for Lucia KPro at the Instituto de Oftalmologia Conde de Valenciana in Mexico City from 2021 to 2023. Multivariate regression analysis and Kaplan-Meier plots were performed to identify associations with functional failure.

Mitomycin Intravascular Chemoembolization for Corneal Neovascularization.

Purpose: The purpose of the study was to evaluate the efficacy of mitomycin C intravascular chemoembolization (MICE) for corneal neovascularization (CNV).

Methods: This is a prospective, nonrandomized, interventional study. Patients with stable CNV irrespective of the underlying etiology were enrolled in the study.

The ILux compared to the mechanical meibomian gland expression for the treatment of moderate and severe meibomian gland dysfunction.

Aim: To compare the safety and effectiveness of eyelid treatment with the ILux-MGD Treatment System in one session versus five sessions of mechanical meibomian gland expression (MMGE) in patients with moderate to severe meibomian gland dysfunction (MGD).

Methods: A prospective, randomized, open-label, and controlled clinical trial that compared one session of the ILux MGD Treatment System versus five sessions of MMGE in both eyes of 130 patients aged ≥18y with Ocular Surface Disease Index (OSDI) scores ≥13, total meibomian gland scores (MGS) of <15 in the lower eyelid of each eye, and non-invasive tear break-up time (NI-TBUT) <10s, who were randomized 1:1 to ILux or MMGE.

Results: The mean age was 58±17.

Neurotrophic keratopathy: General features and new therapies.

Neurotrophic keratopathy is an uncommon degenerative corneal disorder characterized by compromised corneal sensory innervation resulting in the formation of epithelial defects and nonhealing corneal ulcers. Various treatment modalities are available to stabilize disease progression, improve patient well-being, and prevent vision loss. For eligible patients, medical and surgical reinnervation have emerged as pioneering therapies, holding promise for better management.

Delayed-onset pressure-induced interlamellar stromal keratitis (PISK) and interface epithelial ingrowth 10 years after laser-assisted in situ keratomileusis.

Purpose: To report a case of pressure-induced interlamellar stromal keratitis (PISK) 10 years after laser assisted in situ keratomileusis (LASIK).

Observations: A case of a 36-year-old man who underwent LASIK and presented with PISK 10 years later. Before presenting to our department he consulted elsewhere for red eye, decreased visual acuity, foreign body sensation, and pain on the RE for 1 week.

Use of Amniotic Membrane Transplant and Deep Anterior Keratoplasty in a Patient with Bilateral Acanthamoeba Infectious Keratitis: A Case Report.

The aim of this study was to report a case with the use of amniotic membrane transplant and deep anterior keratoplasty in a patient with bilateral Acanthamoeba infectious keratitis as a treatment. A 20-year-old male presented with bilateral Acanthamoeba keratitis (AK) who was initially diagnosed with herpetic keratitis receiving full antiviral and corticosteroid topical treatment without any improvement. Corneal biopsy was performed to confirm the suspected diagnosis, and Acanthamoeba stromal cysts were identified in the sample.

Ophthalmic findings in patients with autosomal recessive lamellar ichthyosis due to TGM1 mutations in an isolated population.

Purpose: To describe the ocular clinical characteristics of a group of Mexican patients with lamellar ichthyosis (LI) arising from TGM1 pathogenic variants.

Methods: Ophthalmological exploration, pedigree analysis and genetic screening were performed in patients with an established clinical diagnosis of lamellar ichthyosis from families located in a small community in the Southeast of Mexico.

Results: Nine patients with LI in five families were identified.