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Trityl chloride (TrCl) was efficiently used as a neutral catalyst for the multicomponent cyclization reaction of an aldehyde with dimedone and 6-amino-1,3-dimethyluracil for the preparation of pyrimido[4,5-b] quinolines in chloroform under reflux condition.
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http://dx.doi.org/10.1038/s41598-023-43793-5 | DOI Listing |
Nanoscale Adv
August 2025
Chemistry Department, College of Sciences, Shiraz University Shiraz 71946-84795 Iran
In this research, Ag@SiO nanoparticles were prepared by a sol-gel method (a wet chemical method) at room temperature. The nanoparticles were functionalized by chlorosulfonic acid to introduce acidic sites on the surface to obtain sulfonic acid grafted on silica-coated silver nanoparticles (Ag@SiO-SOH). Ag@SiO-SOH was identified and characterized by FT-IR, DLS, ZP, FE-SEM, EDX-mapping, TEM, XRD, BET, BJH and TGA analyses.
View Article and Find Full Text PDFBioorg Chem
August 2025
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India. Electronic address:
The battle against cancer remains a critical challenge in medical science, with traditional and targeted therapies showing limited efficacy, especially in metastatic cases. A significant factor in cancer's resilience is multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters, such as ABCB1, ABCC1, and ABCG2. This review emphasizes the urgent need for novel inhibitors targeting these transporters to overcome MDR.
View Article and Find Full Text PDFJ Fluoresc
March 2025
Department of Physics, University of Neyshabur, P. O. Box 9319774400, Neyshabur, Iran.
Nonlinear optical (NLO) properties of thiazolopyrimidoquinoline derivatives containing different substituents on the benzene ring were studied. Correlation between the molecular structure and the dipole moment of compounds investigated by the Z-scan technique and density functional theory (DFT) of the Gaussian 09 program. All the structures were optimized at the M06-2X/6-311G level.
View Article and Find Full Text PDFAntioxidants (Basel)
November 2024
College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
MsrB1 is a thiol-dependent enzyme that reduces protein methionine--sulfoxide and regulates inflammatory response in macrophages. Therefore, MsrB1 could be a promising therapeutic target for the control of inflammation. To identify MsrB1 inhibitors, we construct a redox protein-based fluorescence biosensor composed of MsrB1, a circularly permutated fluorescent protein, and the thioredoxin1 in a single polypeptide chain.
View Article and Find Full Text PDFBiomed Pharmacother
November 2024
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: