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Macromastia is a common condition that can lead to physical pain, emotional burden, and behavioral impairment, with significant decrements in quality of life. Reduction mammaplasty offers the only effective treatment of symptomatic macromastia, and patients experience significant improvements in their physical and psychosocial health through surgical correction. Although symptoms typically arise during adolescence, most women seeking surgical intervention do not undergo reduction mammaplasty until their fifth decade of life. Providers often delay surgery due to speculative concerns about emotional immaturity, postoperative breast regrowth, and future lactation performance. The strict guidelines related to age and body mass index imposed by insurance companies further restrict the options available to younger patients with macromastia. This review offers an evidence-based approach to treating macromastia in younger patients. After more than 15 years of treatment and research centered on adolescents and young adults with macromastia led by the senior author (B.I.L.), a pediatric plastic surgeon, we have found that reduction mammaplasty is a safe and effective treatment option for this patient population. It is our hope that our work will enable care providers to make data-supported decisions when treating younger patients with symptomatic macromastia.
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http://dx.doi.org/10.1097/PSN.0000000000000521 | DOI Listing |
Ann Plast Surg
September 2025
From the Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN.
Background: The practice of systemic antibiotic prophylaxis to prevent surgical site infection (SSI) in breast surgery remains debated. The aim of this review is to provide a comprehensive overview of the literature evaluating the current evidence on the efficacy of antibiotic prophylaxis in nononcologic breast surgery, including risk-reducing mastectomy, gender-affirming mastectomy, augmentation, and reduction.
Methods: A literature search of PubMed and Cochrane databases of 1990-2025 was conducted to identify studies evaluating antibiotic prophylaxis and SSI outcomes in nononcologic breast surgery.
Medicina (Kaunas)
July 2025
Department of Orthopedic Surgery, Wolfson Medical Center, Holon 5822012, Israel.
: The association between female breast size and spinal back pain is widely suggested in clinical practice but remains insufficiently quantified in general, non-surgical populations in the scientific literature. Larger breasts may increase biomechanical strain on the spine, contributing to musculoskeletal pain and reduced quality of life. This study aimed to evaluate the association between breast size and back pain in a general orthopedic population of young women.
View Article and Find Full Text PDFPlast Reconstr Surg
August 2025
Graduate Program in Translational Surgery, Universidade Federal de São Paulo, São Paulo - SP, Brazil.
Background: This trial aimed to compare the influence of administering a single dose or 24h of prophylactic antibiotics on surgical site infection (SSI) rates after reduction mammaplasty.
Methods: This is a randomized, non-inferiority, parallel-arm clinical trial with a 1:1 allocation ratio. One hundred forty-six participants undergoing reduction mammaplasty were randomly assigned to the placebo group (PG), which received cefazolin 1g at the time of anesthesia induction (n=73), or to the antibiotic group (AG), which received cefazolin 1g at the time of anesthesia induction and every 6h for 24h (n=73).
Aesthetic Plast Surg
August 2025
Department of Surgical, Microsurgical and Medical Sciences, Plastic Surgery Unit, University of Sassari, Sassari, Italy.
Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.
View Article and Find Full Text PDFSwiss Med Wkly
July 2025
Department of Hand and Plastic Surgery, Thurgau Hospital Group, Frauenfeld, Switzerland.
Background: Reduction mammoplasty is commonly used to treat macromastia, highlighting the need to address the physical and psychosocial issues associated with breast hypertrophy. However, clear inconsistencies in insurance coverage and varying criteria for medically necessary surgery are evident. The compliance of Swiss insurance companies with the 2019 recommendations of the Swiss Society of Medical Officers and Insurance Physicians has not been fully assessed.
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