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Objective: The aim of the study is to explore the potential of a sitting reduction workplace intervention for improving stress and work performance.
Methods: A cluster randomized controlled trial evaluated an intervention to reduce and break up occupational sitting in 12 clusters ( n = 89 office workers) over 8 weeks. Outcomes were physiological stress (cortisol concentrations), perceived stress, and work performance.
Results: Linear mixed model group × time interaction effects were nonsignificant. Exploratory analyses showed a trend, with a large effect, for lower cortisol concentrations over the day in the intervention group relative to controls at 8 weeks (-0.85; 95% confidence interval, -1.70 to 0.03 nmol·L -1 ; P = 0.06, d = 0.79). The intervention group had higher vigor and cognitive liveliness at 8 weeks relative to controls ( P ≤ 0.05).
Conclusions: This exploratory study suggests that there could be meaningful changes in physiological stress and work-related outcomes that should be investigated in future studies.
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http://dx.doi.org/10.1097/JOM.0000000000002971 | DOI Listing |
J Am Chem Soc
September 2025
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.
Photodynamic therapy (PDT) induces oxidative stress that triggers a compensatory upregulation of intracellular glutathione (GSH), thereby diminishing PDT efficacy. The simultaneous generation of reactive oxygen species and depletion of GSH holds promise for amplifying oxidative damage and enhancing therapeutic outcomes yet remains a challenge. In this work, we present a Type-I supramolecular photosensitizer designed to deplete GSH through a hydrogen atom transfer mechanism while concurrently generating superoxide radicals.
View Article and Find Full Text PDFToxicol Mech Methods
September 2025
Laboratory of Mutagenesis, Institute of Biological Sciences (ICB I), Federal University of Goias, Goiania, Goias, Brazil.
While agriculture is essential for food security, the intensive use of pesticides in modern farming practices raises concerns on their impact, in particular from a One Health perspective. In 2024, Brazil approved 663 new pesticides, a 19% increase in comparison with 2023. The occupational exposure of rural workers is known to be associated with a range of health outcomes, including cancer.
View Article and Find Full Text PDFSchizophr Bull
September 2025
Department of Psychiatry, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Background And Hypothesis: Schizophrenia is linked to hippocampal dysfunction and microglial inflammatory activation. Our prior clinical findings revealed significantly reduced transient receptor potential vanilloid 1 (TRPV1) expression in both first-episode and recurrent schizophrenia patients, with levels inversely correlating with symptom severity, implicating TRPV1 dysfunction in disease progression. Preclinical maternal separation (MS) models recapitulate schizophrenia-like behavioral and synaptic deficits, paralleled by hippocampal microglial TRPV1 downregulation.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Dermatology, Yulin First Hospital, Yulin, Shaanxi Province, China.
Background: Psoriasis is linked with an elevated risk of anxiety disorders, and there may be a temporal relationship between the two. However, the association between anxiety status and its duration with psoriasis is unclear.
Objectives: The present work aimed to figure out the association between anxiety and the risk of psoriasis.
Eur J Dent Educ
September 2025
University of Hong Kong, Hong Kong, China.
Introduction: Supporting wellbeing of staff involved in dental education is vital to ensure the safe effective delivery of the curriculum and training of the dental workforce. There are only a limited number of studies on the stress and wellbeing of staff involved in dental education and the barriers they face in engaging with any wellbeing services provided. To plan strategies for the promotion of staff wellbeing, it is important to identify these and the barriers faced by staff.
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