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To summarize and clarify the current research status and indicate possible future directions in the field of autophagy in ischemic stroke, we performed a comprehensive and multidimensional bibliometric analysis of the literature in this field published from 2011 to 2022. We retrieved articles on the field of autophagy in ischemic stroke published between 2011 and 2022 from Web of Science Core Collection (WOSCC). VOSviewer (version 1.6.19) and CiteSpace (version 6.2.R2 Basic) were used to identify the leading topics as well as generate visual maps of Countries/regions, organizations, authors, journals, and keyword networks in the related field. A total of 568 publications were contained in this research. The journal with the most publications were Front Pharmacol, Mol Neurobiol, and Neuroscience. China was the most productive country with respect to co-authorship, with the Capital Med Univ being the organization with the most. co-authorships. In terms of authorship analysis, eight of the top 10 most contributive authors were from China. The co-occurring author keywords can be divided into three main clusters, including "protective effect of autophagy in ischemic stroke," "autophagy-targeted therapy for ischemic stroke," and "mitochondrial function in cerebral ischemia-reperfusion injury". This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.
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http://dx.doi.org/10.3389/fphar.2023.1232114 | DOI Listing |
Front Pharmacol
August 2025
Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Introduction: Ischemic stroke is a leading cause of mortality and disability worldwide, with limited therapeutic options and high rates of recurrence. Mitochondrial dysfunction plays a critical role in neuronal injury during ischemia-reperfusion, making mitochondrial autophagy a potential therapeutic target. Gypenoside XLIX, a major active metabolite of Gynostemma pentaphyllum, exhibits antioxidant and organ-protective properties, but its effects on neuronal mitochondrial damage in stroke remain unclear.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Institute of Biomedical Sciences, Faculty of Medicine, 8380000 Santiago, Chile.
Acute myocardial infarction (AMI) is one of the main causes of mortality worldwide. Currently, the most effective treatment is percutaneous coronary angioplasty (PCA). However, paradoxically, the restoration of blood flow induces myocardial reperfusion injury (MRI), contributing up to 50% of the final infarct size.
View Article and Find Full Text PDFNeuropharmacology
September 2025
College of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China. Electronic address:
Aim Of The Study: This study aimed to investigate the protective effects of Geniposide (GEN) against cerebral ischemia-reperfusion injury by targeting the cGAS-STING pathway and modulating autophagy in neuronal cells.
Materials And Methods: In vivo middle cerebral artery occlusion/reperfusion (MCAO/R) model and an in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model to mimic the pathology of cerebral ischemic stroke in humans. Behavioral tests, tissue staining to assess neurological deficits and tissue damage in mice.
J Mol Histol
September 2025
Ultrasonography Department, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Quanzhou, 362200, China.
Renal ischemic disease represents a severe clinical pathological condition commonly observed in acute kidney injury (AKI), renal transplantation, and kidney surgery. It leads to renal tubular epithelial cell damage, inflammatory responses, and cell death, potentially progressing to chronic kidney disease (CKD) or even renal failure, significantly impairing patients' quality of life and survival rates. Current therapeutic strategies for renal ischemia-reperfusion injury (IRI) include pharmacological interventions, cell therapy, and gene therapy, yet their efficacy remains limited and may be accompanied by adverse effects.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Aim: Ischemia-reperfusion (IR) injury-induced renal failure is a major cause of death and morbidity. Unfortunately, there is currently no proven protective therapy. The aim of the study is to investigate the protective effect of D-carvone against the renal ischemia-reperfusion (RIR) injury.
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