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We demonstrate a two-dimensional, individually tunable electrowetting microlens array fabricated using standard microfabrication techniques. Each lens in our array has a large range of focal tunability from -1.7 mm to -∞ in the diverging regime, which we verify experimentally from 0 to 75 V for a device coated in Parylene C. Additionally, each lens can be actuated to within 1% of their steady-state value within 1.5 ms. To justify the use of our device in a phase-sensitive optical system, we measure the wavefront of a beam passing through the center of a single lens in our device over the actuation range and show that these devices have a surface quality comparable to static microlens arrays. The large range of tunability, fast response time, and excellent surface quality of these devices open the door to potential applications in compact optical imaging systems, transmissive wavefront shaping, and beam steering.
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http://dx.doi.org/10.1364/OE.497992 | DOI Listing |
J Ultrasound Med
September 2025
Department of Ultrasound, Donghai Hospital Affiliated to Kangda College of Nanjing Medical University, Lianyungang, China.
Objective: The aim of this study is to evaluate the prognostic performance of a nomogram integrating clinical parameters with deep learning radiomics (DLRN) features derived from ultrasound and multi-sequence magnetic resonance imaging (MRI) for predicting survival, recurrence, and metastasis in patients diagnosed with triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC).
Methods: This retrospective, multicenter study included 103 patients with histopathologically confirmed TNBC across four institutions. The training group comprised 72 cases from the First People's Hospital of Lianyungang, while the validation group included 31 cases from three external centers.
J Am Soc Echocardiogr
September 2025
Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Introduction: Repaired total anomalous pulmonary venous connection (TAPVC) patients with preoperative pulmonary venous obstruction (PVO) have reductions in echocardiographic metrics, such as left atrial reservoir function and pulmonary venous variability index (PVVI). We hypothesized reduced preoperative left atrial strain mechanics in isolated TAPVC patients serve as risk factors for postoperative PVO. We also evaluated echocardiographic metrics and clinical characteristics associated with preoperative and postoperative PVO, as well as compared these to healthy controls.
View Article and Find Full Text PDFJ Neurosci Methods
September 2025
Department of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Background: Cortico-cortical evoked potentials (CCEPs), elicited via single-pulse electrical stimulation, are used to map brain networks. These responses comprise early (N1) and late (N2) components, which reflect direct and indirect cortical connectivity. Reliable identification of these components remains difficult due to substantial variability in amplitude, phase, and timing.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
Background: Advanced diffusion models have been introduced to improve characterization of tissue microstructure in breast cancer assessment.
Purpose: This study aimed to evaluate the diagnostic utility of monoexponential apparent diffusion coefficient (ADC), time-dependent diffusion magnetic resonance imaging (td-dMRI), and the Continuous-Time Random-Walk (CTRW) diffusion model for differentiating breast lesions and predicting Ki-67 expression levels.
Methods: Fifty-three consecutive patients with suspected breast lesions undergoing preoperative MRI were enrolled in this prospective investigation.
Diabetes
September 2025
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Unlabelled: Deciphering the heterogeneity of type 2 diabetes in prognosis and treatment effect is essential. We used a novel dimensionality reduction approach to describe the type 2 diabetes phenotype continuum and visualize the difference in lifestyle intervention efficacy in Chinese patients. Based on 17,816 participants with newly diagnosed type 2 diabetes (aged ≥40 years) from a nationwide cohort, 12 key phenotypes were residualized for age and sex to construct a two-dimensional tree structure.
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