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Article Abstract
Mutation of the MAPK7 gene was related to human scoliosis. regulated the development of limb bones and skulls in mice. However, the role of MAPK7 in vertebral development is still unclear. In this study, we constructed transgenic mouse model to delete in cartilage, which displayed kyphosis and osteopenia. Mechanistically, loss decreased MEF2C expression and thus activated PTEN to oppose PI3K/AKT signaling in vertebral growth plate chondrocytes, which impaired chondrocyte hypertrophy and attenuated vertebral ossification. , systemic pharmacological activation of AKT rescued impaired chondrocyte hypertrophy and alleviated mouse vertebral defects caused by deficiency. Our study firstly clarified the mechanism by which MAPK7 was involved in vertebral development, which might contribute to understanding the pathology of spinal deformity and provide a basis for the treatment of developmental disorders of the spine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491872 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2023.02.012 | DOI Listing |
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