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It is known that Opisthorchis viverrini (OV) is the most significant risk factor for the development of cholangiocarcinoma (CCA); hence, it is also known as carcinogenic parasite. Effective control and elimination of OV infection should significantly reduce O. viverrini-related CCA. This chapter includes details of the three recently developed innovative tools, namely the Isan cohort database software, an OV-RDT for screening of O. viverrini, and an ultrasound telecommunication system. Past and current control programs, i.e., education, medication, and sanitation were discussed and stressed the need for a comprehensive control program which encompasses primary, secondary, and tertiary patient care programs for confirmation and management of suspected CCA cases. The approach of mathematical modeling for control of OV and CCA was also briefly described. Additionally, we highlighted the current progress toward control of OV and CCA in Thailand and potential for expansion into nearby countries in Southeast Asia.
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http://dx.doi.org/10.1007/978-3-031-35166-2_3 | DOI Listing |
J Cancer Educ
September 2025
Department of Health Sciences, Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, 34000, Thailand.
Cholangiocarcinoma (CCA) remains a major public health concern in Thailand, particularly in areas endemic for Opisthorchis viverrini infection. During the period of 2020-2022, there was a rapid shift in public communication behaviors that created new opportunities to promote health education through diverse media channels. This study aimed to assess public awareness of CCA prevention and explore the feasibility of applying social marketing strategies during a time of health crisis.
View Article and Find Full Text PDFJ Infect Dis
September 2025
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 Thailand.
Opisthorchiasis remains a significant public health concern throughout Southeast Asia. The liver fluke Opisthorchis viverrini resides within the biliary tract and chronic infection leads to bile duct cancer, or cholangiocarcinoma. Here, we examined the functions of liver fluke tetraspanins, four-transmembrane domain proteins expressed on the surface of the fluke tegument and extracellular vesicles (EVs) derived from this syncytial surface.
View Article and Find Full Text PDFParasites Hosts Dis
August 2025
Parasitic Disease Research Center, Suranaree University of Technology Institute of Medicine, Nakhon Ratchasima 30000, Thailand.
Acta Trop
August 2025
Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; WHO Collaborating Center for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Diseases), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address
The liver fluke Opisthorchis viverrini causes chronic infections in humans and animals. This helminth is known to coexist with the bacterial microbiome in the host's bile duct, and their interaction potentially impacts the helminth's pathogenicity. While most infected individuals remain asymptomatic, the mechanism of immune modulation remains unclear.
View Article and Find Full Text PDFSci Rep
August 2025
Visual Intelligence Laboratory, Department of Statistics, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Cholangiocarcinoma (CCA) is a prevalent malignancy in countries along Mekong basin, closely linked to chronic infections caused by Opisthorchis viverrini (OV). Early detection of OV-infected individuals holds significant promise for screening at-risk populations in endemic regions. Recent advancements in immunochromatographic methods have led to the development of a rapid diagnostic test (RDT) based on urinary antigens.
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