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Purpose: The purpose of this systematic review is to identify evidence-based interventions to promote active motor learning in children aged 2 to 6 years with bilateral cerebral palsy.
Summary Of Key Points: Seven randomized clinical trials of active motor learning interventions targeting gross motor function and mobility were included. Two studies compared context-focused therapy to child-focused therapy. Five studies compared active motor therapy to usual care. Context-focused therapy, child-focused therapy, and active motor therapy were comparable to usual care to improve functional mobility and gross motor function.
Conclusions And Recommendations For Clinical Practice: There are limited active intervention studies targeting gross motor function for young children with bilateral cerebral palsy. The authors recommend consideration of the clinical good practice guidelines, dosage parameters, and improved reporting methods when implementing active motor learning interventions targeting gross motor function and mobility for children with cerebral palsy.
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http://dx.doi.org/10.1097/PEP.0000000000001041 | DOI Listing |
Alzheimers Res Ther
September 2025
Motor Control and Learning Group, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Leopold-Ruzicka-Weg 4, Zurich, 8093, Switzerland.
J Stroke Cerebrovasc Dis
September 2025
Department of pain medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.. Electronic address:
Background: Ischemic stroke is a leading cause of neurological disability. Current therapies fail to address its multifactorial pathologies. Miltirone, a bioactive compound from Salvia miltiorrhiza, has shown antioxidative and anti-inflammatory potential.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Ethnopharmacological Relevance: Fujian Tablet (FJT), a traditional Chinese herbal compound formulation developed under the theoretical framework of "nourishing the liver and kidney, replenishing essence and marrow" , has been clinically applied for over two decades to treat post-stroke neurological deficits. Preliminary studies demonstrated its efficacy in improving motor function and promoting cervical spinal cord neuroaxonal growth in a middle cerebral artery occlusion (MCAO) rat model. Building upon these findings, this study integrates metabolomic evidence of Foxo3a-GPX4 axis activation to systematically elucidate Fujian Tablet's neurorestorative mechanisms through three interconnected pathways: regulation of ferroptosis, promotion of oligodendrocyte proliferation, and remyelination.
View Article and Find Full Text PDFJ Electromyogr Kinesiol
September 2025
Biomedical Engineering Program (COPPE), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Evidence on regional muscle excitation within hamstrings remains controversial, primarily because information derived solely from surface electromyograms (sEMG) amplitude does not necessarily provide an accurate estimate of neural drive to the muscle. To address this limitation, this study investigated whether there are proximodistal differences in motor unit properties of the biceps femoris long head during isometric hip extension and knee flexion tasks. Seventeen resistance-trained males performed isometric knee flexion and hip extension tasks at 20 % and 40 % of maximal voluntary contraction.
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, USA.
Cognitive decline and physical impairment are often linked with ageing, contributing to declines in health span and loss of independence in older adults. Pathological cognitive decline with age is largely considered to be a brain-centric challenge. However, recent findings have begun to challenge this paradigm as the health of peripheral systems, namely skeletal muscle, predict cognitive decline associated with Alzheimer's disease (AD).
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