Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Circulating endotoxins could result from bacterial digestive translocation during sepsis, thus contributing to uncontrolled systemic inflammation, leading in turn to organ dysfunction. We addressed this issue in the setting of severe pneumococcal pneumonia.
Methods: Endotoxemia was measured in a clinically relevant rabbit model of ventilated pneumococcal pneumonia and in 110 patients with bacteraemic pneumonia, using a patented mass spectrometry (LC-MS/MS) method for detection of 3-OH fatty acids (C10, C12, C14, C16 and C18), which are molecules bound to the lipid A motif of LPS.
Results: Whereas higher levels of systemic inflammation and organ dysfunctions were found, there was no significant difference in lipopolysaccharide concentrations when infected rabbits were compared to non-infected ones, or when patients were compared to healthy volunteers.
Conclusions: Seemingly, endotoxins do not drive the overwhelming inflammation associated with severe forms of pneumococcal pneumonia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/eci.14077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Erratum for "Association Between Introduction of the 23-valent Pneumococcal Polysaccharide Vaccine (PPSV23) and Pneumonia Incidence and Mortality Among General Older Population in Japan: A Community-based Study."J Epidemiol 35(5) (2025) 237-244.
J Epidemiol
September 2025
Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Changes in carriage and serotype diversity of Streptococcus pneumoniae and other respiratory pathobionts in the UK between pre-PCV13 (2006-10), early-PCV13 (2010-12) and late-PCV13 (2012-23) periods.
Pneumonia (Nathan)
September 2025
Faculty of Medicine, Institute for Life Sciences, University of Southampton, Southampton, UK.
Background: The ongoing burden of mortality and morbidity associated with infections requires that monitoring of carriage epidemiology continues. Here, we present data from the annual, cross-sectional surveillance study in Southampton UK on serotype epidemiology and diversity, as well as carriage of other frequent colonisers of the respiratory tract in over 7000 children over a period of seventeen years (2006–2023).
Methods: Children were recruited from two sites: Site 1 - Southampton General Hospital, administered by University Hospital Southampton (UHS) NHS Foundation Trust and Site 2– a collection of community health care facilities within the Solent NHS Trust region.
Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis.
J Hazard Mater
August 2025
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Allergy, Asthma, and Rheumatology, Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital at Li
Microplastics (MPs) are ubiquitous environmental pollutants posing serious concerns owing to their potential health implications. MPs exert detrimental effects via the plastic particles, MP-bound chemicals, and MP-carrying pathogens. Streptococcus pneumoniae (pneumococcus) is a major pathogen causing bacterial pneumonia and respiratory inflammation.
View Article and Find Full Text PDFThe significance of upper airway density of Streptococcus pneumoniae and respiratory viruses in the aetiology and severity of paediatric community-acquired pneumonia in Norway: An observational study.
J Microbiol Immunol Infect
August 2025
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Norway; Children's Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Objectives: Diagnosing paediatric Community-Acquired Pneumonia (CAP) is challenging due to the difficulty in obtaining lung specimens. Studies suggest that the upper-airway density of Streptococcus pneumoniae is related to the risk and severity of CAP. We studied the association between S.
View Article and Find Full Text PDFAssessing the impact of childhood pneumococcal vaccination on pneumonia mortality in Colombia: a 14-year analysis.
BMC Public Health
September 2025
Universidad Nacional de Colombia, Bogotá, Colombia.
Background: The 10-valent pneumococcal conjugate vaccine (PCV10) has been offered to all infants through Colombia’s National Immunization Program (NIP) since 2012, with catch-up vaccination until age 5. However, pneumococcal vaccination is not currently included in the NIP for other age groups, such as those ≥ 5 years with medical conditions or older adults. This study assessed the pediatric PCV10 effect on pneumonia mortality rate (MR) trends across different age groups from 2006 to 2019.
View Article and Find Full Text PDF