Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: To investigate the impact of a pre-emptive apnoea triggered oxygen response on oxygen saturation (SpO) targeting following central apnoea in preterm infants.
Design: Interventional crossover study of a 12-hour period of automated oxygen control with an apnoea response (AR) module, nested within a crossover study of a 24-hour period of automated oxygen control compared with aggregated data from two flanking 12-hour periods of manual control.
Setting: Neonatal intensive care unit PATIENTS: Preterm infants receiving non-invasive respiratory support and supplemental oxygen; median (IQR) birth gestation 27 (26-28) weeks, postnatal age 17 (12-23) days.
Intervention: Automated oxygen titration with an automated control algorithm modified to include an AR module. Alterations to inspired oxygen concentration (FiO) were actuated by a motorised blender. Desired SpO range was 90-94%. Apnoea detection was by capsule pneumography.
Main Outcome Measures: Duration, magnitude and area under the curve (AUC) of SpO deviations following apnoea; frequency and duration of apnoeic events. Comparisons between periods of manual, automated and automated control with AR module.
Results: In 60 studies in 35 infants, inclusion of the AR module significantly reduced AUC for SpO deviations below baseline compared with both automated and manual control (manual: 87.1%±107.6% s, automated: 84.6%±102.8% s, AR module: 79.4%±102.7% s). However, there was a coincident increase in SpO overshoot (AUC (SpO>SpO); manual: 44.3±99.9% s, automated: 54.7%±103.4% s, AR module: 65.7%±126.2% s).
Conclusion: Automated control with a pre-emptive apnoea-triggered FiO boost resulted in a modest reduction in post-apnoea hypoxaemia, but was followed by a greater SpO overshoot.
Trial Registration Number: ACTRN12616000300471.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/archdischild-2023-325849 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The interplay between sleep and neural respiratory drive in COPD: contribution of semi-automated analysis of long duration recordings.
Neuroimage
September 2025
UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, INSERM, Sorbonne Université, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département R3S, Paris, France. Electronic address:
Background: Neural respiratory drive (NRD) is a clinically relevant biomarker in patients with chronic obstructive pulmonary disease (COPD). However, its analysis is challenging due to several technical considerations, including the need to obtain a stable recording over a short time period. However, a short recording duration may be inadequate to comprehensively record clinically relevant information, particularly during sleep, because NRD varies across sleep stages and over time.
View Article and Find Full Text PDFExplainable mortality prediction models incorporating social health determinants and physical frailty for heart failure patients.
PLoS One
September 2025
Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, China.
There is limited evidence on how social determinants of health (SDOH) and physical frailty (PF) influence mortality prediction in heart failure (HF), particularly for in-hospital, 90-day, and 1-year outcomes. This study aims to develop explainable machine learning (ML) models to assess the prognostic value of SDOH and PF at multiple time points. We analyzed data from adult patients admitted to the intensive care unit (ICU) for the first time with a diagnosis of HF.
View Article and Find Full Text PDFAlterations in diaphragmatic activity preceding and during intermittent hypoxaemia events in preterm infants.
BMJ Paediatr Open
September 2025
Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Objective: To assess the activity of the diaphragm using electromyography (dEMG) prior and during apnoea-induced intermittent hypoxaemia (IH) events in preterm infants DESIGN: A single-centre observational study.
Setting: Neonatal intensive care unit.
Patients: Preterm infants (<32 weeks of gestation) experiencing IH events with a frequency of >1/hour METHODS: Heart rate, oxygen saturation (SpO) and dEMG were measured for 24 hours.
One-step electrochemical conversion of propane to acetone of 96% purity.
Nat Commun
August 2025
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Acetone is a crucial chemical and solvent with extensive industrial applications, traditionally synthesized from propane through multi-step processes that demand high temperatures and pressures. Here, we report a selective one-step conversion of propane to acetone using a heterogeneous electro-Fenton process (h-EFP) under mild conditions. In this process, concentrated ·OH radicals are generated in an iron/carbon hybrid cathode via a two-electron oxygen reduction reaction followed by HO conversion.
View Article and Find Full Text PDFPredicting Episodes of Hypovigilance in Intensive Care Units Using Routine Physiological Parameters and Artificial Intelligence: Derivation Study.
JMIR AI
August 2025
Centre de recherche intégrée pour un système apprenant en santé et services sociaux, Centre intégré de santé et de services sociaux de Chaudière-Appalaches, Lévis, QC, Canada.
Background: Delirium is prevalent in intensive care units (ICUs), often leading to adverse outcomes. Hypoactive delirium is particularly difficult to detect. Despite the development of new tools, the timely identification of hypoactive delirium remains clinically challenging due to its dynamic nature, lack of human resources, lack of reliable monitoring tools, and subtle clinical signs including hypovigilance.
View Article and Find Full Text PDF