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An experimental testing system for the two-dimensional (2D) fuze overload loading process was designed to address the loading issues of recoil overload and centrifugal overload in fuze safety and arming (S&A) device. By incorporating centrifuge rotation energy storage, impact acceleration simulation, and equivalent centrifugal rotation simulation, a block equipped with a fuze S&A device accelerated instantly upon having impact from a centrifuge-driven impact hammer, simulating recoil overload loading. The impact hammer was retracted instantaneously by adopting an electromagnetic brake, which resulted in the centrifugal rotation of the block around its track, to simulate the centrifugal overload loading. The dynamic equations of the experimental testing system and the equations of impact hammer motions were established, whereby the rotation speed of the centrifuge and the braking force of the electromagnetic brake were calculated and selected. A dynamic model of the collision between the impact hammer and block was established using ANSYS/LS-DYNA software for simulation analysis. The acceleration curves of the recoil overload and centrifugal overload with variations in the centrifuge speed, cushion material, and buffer thickness were obtained, which verified the feasibility of the proposed loading simulation method. Two-dimensional overload loading simulation tests were performed using the developed experimental testing system, and the acceleration curves of the recoil overload and centrifugal overload were measured. The test results indicated that the proposed system can accomplish 2D overload loading simulations for a recoil overload of several 10,000× and centrifugal overload of several 1000× .
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http://dx.doi.org/10.3390/mi14081566 | DOI Listing |
Mol Cell Biol
September 2025
Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Erythropoiesis, i.e., process of red blood cell (RBC) production, is highly dependent on iron, with 60-70% of the total body iron incorporated into hemoglobin.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
September 2025
University Clinic for Orthopedic Surgery and Traumatology, Kantonsspital Baselland, Bruderholz, Switzerland.
Kinematic alignment is increasingly adopted in total knee arthroplasty (TKA) as a patient-specific strategy to restore native joint anatomy. However, its reliance on static radiographic measurements may not adequately reflect real-world functional biomechanics. This editorial underscores the importance of complementing static assessment with kinetic principles.
View Article and Find Full Text PDFClin Implant Dent Relat Res
October 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Introduction: This in vitro study evaluated how different forces applied to the dental drill handle during static computer-assisted implant surgery influence surgical guide deformation and implant placement accuracy.
Methods: Twenty-four virtual implants were divided into six groups (0-10 N, in 2 N increments). Surgical guides were scanned under loaded conditions, and deviations were quantified by superimposition with the baseline model.
J Orthop Translat
November 2025
AO Research Institute Davos, Davos, Switzerland.
Background/objective: Plate failure, including bending, is a critical issue in orthopedic fracture fixation, with clinical failure rates of 3.5%-19%, burdening patients and healthcare systems. Preclinical ovine models have observed similar plate bending due to overloading.
View Article and Find Full Text PDFBiomaterials
August 2025
Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, PR China.
Amino acid (AA)-based nanoparticles (NPs) hold promise in cancer therapy due to their excellent biocompatibility and the various therapeutic functions derived from AA monomers. Here, we developed a universal one-step method to synthesize AA-based NPs. We then constructed L-Arginine (L-Arg)/calcium phosphate (CaP) NPs to enhance cancer therapy through synergistic calcium overload to induce apoptosis and immunogenic cell death.
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