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Ulcerative colitis (UC) is a chronic inflammatory bowel disease primarily affecting the colon and rectum. Endoscopy plays a crucial role in the diagnosis and management of UC. Recent advancements in endoscopic technology, including chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and the use of artificial intelligence, have revolutionized the assessment and treatment of UC patients. These innovative techniques enable early detection of dysplasia and cancer, more precise characterization of disease extent and severity and more targeted biopsies, leading to improved diagnosis and disease monitoring. Furthermore, these advancements have significant implications for therapeutic decision making, empowering clinicians to carefully consider a range of treatment options, including pharmacological therapies, endoscopic interventions and surgical approaches. In this review, we provide an overview of the latest endoscopic technologies and their applications for diagnosing and monitoring UC. We also discuss their impact on treatment decision making, highlighting the potential benefits and limitations of each technique.
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http://dx.doi.org/10.3390/biomedicines11082139 | DOI Listing |
Acta Biochim Biophys Sin (Shanghai)
September 2025
State Key Laboratory of Analytical Chemistry for Life Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Dysregulated transcription factors critically link chronic inflammation to oncogenesis in colitis-associated colorectal cancer (CAC), but their mechanistic roles remain incompletely understood. By integrating microarray and transcriptome sequencing data from ulcerative colitis (UC), colitis-associated cancer (CAC), and colorectal cancer (CRC) patients, we identify C/EBPβ as a key transcriptional regulator whose elevated expression inversely correlates with survival. In azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC models, intestinal epithelial C/EBPβ is upregulated during tumor progression, which is correlated with exacerbated tumor burden and neutrophil infiltration.
View Article and Find Full Text PDFAliment Pharmacol Ther
September 2025
National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals, Nottingham, UK.
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian randomisation (MR) analysis was conducted using genome-wide association study datasets for endometriosis and IBD, including ulcerative colitis and Crohn's disease. Causal inference was assessed using inverse variance weighting, MR-Egger, and weighted median methods, with MR-PRESSO used to detect horizontal pleiotropy.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Gastroenterology, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, China.
Prior observational studies suggested an association between chronic rhinosinusitis (CRS) and inflammatory bowel disease (IBD), but causality remains unclear. This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis to investigate potential causal relationships. Genetic variants associated with CRS and IBD (including Crohn's disease and ulcerative colitis) were sourced from the IEU Open genome-wide association study project.
View Article and Find Full Text PDFFood Res Int
November 2025
Center for Cancer Immunology, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), 1068 Xueyuan Avenue, Shenzhen 518055, China. Electronic address:
Inflammatory bowel disease (IBD) encompasses two main conditions: Crohn's disease and ulcerative colitis. The role of foodborne pathogens, often transmitted through contaminated food, is a subject of ongoing research regarding their potential involvement in IBD. The most common foodborne pathogens S.
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