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http://dx.doi.org/10.1007/s11427-023-2384-9 | DOI Listing |
J Mol Cell Cardiol
September 2025
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
Selective therapeutic targeting of cardiomyocytes (CMs) and non-myocytes (NMs) within the heart is an active field of research. The success of those novel therapeutic strategies is linked to the ability to accurately assess uptake and gene delivery efficiencies in clinically relevant animal models. Nevertheless, quantification at the single cell level remains a significant challenge.
View Article and Find Full Text PDFDNA Cell Biol
September 2025
College of Veterinary Medicine, University of Sulaimani, Sulaimaniya, Iraq.
Probiotics sourced from host-adapted microbes represent a sustainable innovation in aquaculture nutrition, aiming to replace antibiotics and enhance fish health. However, studies evaluating indigenous probiotic strains specifically adapted to the gut environment of target species remain limited. In this study, an indigenous strain was isolated from common carp () intestine, PCR-authenticated via dual endoglucanase amplicons (545 and 1311 bp), formulated as a powdered feed additive, and tested at 1, 10, and 100 mg/kg against commercial Nutri-Fish®, Infloran Bio®, vitamin C, and a supplemented control in an 8-week feeding trial with ( = 126) carp.
View Article and Find Full Text PDFCell Signal (Middlet)
January 2025
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA.
Aging contributes significantly to the deterioration of cardiac function and increases the prevalence of heart failure, including those with reduced or preserved ejection fraction. Heart failure with preserved ejection fraction (HFpEF) is highly prevalent in the elderly population and it has become a leading cause of morbidity and mortality in this group. This commentary discusses the important findings and broader implications of the study by Daneshgar .
View Article and Find Full Text PDFActa Pharm Sin B
August 2025
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Mitochondrial DNA (mtDNA) acts as a damage-associated molecular pattern to activate the stimulator of interferon genes (STING) signaling in macrophages, promoting tissue inflammation. However, its role in acute myocardial infarction (AMI) remains unclear. Macrophage-specific knockout mice were used to validate STING's pathological role in AMI.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
September 2025
Liuzhou Key Laboratory of Birth Defects Prevention and Control, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, 545000, Guangxi, China.
Objective: To evaluate the clinical characteristics, pregnancy and neonatal outcomes of cytomegalovirus (CMV) infection in pregnant women.
Methods: This retrospective study included 22,673 pregnant women from Liuzhou, Guangxi, China, between 2018 and 2024. Amniotic fluid samples collected during mid-to-late pregnancy were tested for CMV DNA.