Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To observe and analyse the hearing outcome in infants with mild-to-moderate sensorineural hearing loss (SNHL) who failed universal newborn hearing screening (UNHS).
Methods: This retrospective cohort analysis included infants with mild-to-moderate SNHL and with complete etiological diagnosis and followed up over three years.
Results: Out of 96 infants with mild-to-moderate SNHL 72 were stable (75%). Only one case was normal (1.04%), ten cases were improved (10.42%), and 13 were deteriorated (13.54%). The pathogenic mutation of GJB2 was the most common cause (50/96, 52.08%), and most of them were homozygous or complex heterozygous mutations of p.V37I (44/50, 88%). There were 11 cases (11.49%) with large vestibular aqueduct syndrome (LVAS) and nine cases (9.38%) with perinatal risk factors. Infants with GJB2 pathogenic mutation and those without certain etiology mostly had unchanged hearing levels, accounting for 84% (42/50) and 84.61% (22/26), respectively. Hearing deterioration in LVAS was associated with seven cases (63.64%). There was no difference in types of outcomes in perinatal risk factor infants, who were more likely to improve than the other groups, but there were three cases (33.3%) deteriorated to profound hearing loss. Comparison of outcomes of different etiologies showed statistically significant difference (Chi-square = 28.673, p = 0.000).
Conclusion: Normal and improved hearing in infants with mild-to-moderate SNHL was rare before the age of three, unlike in many previous studies, and appropriate intervention is recommended. However, intervention should be adjusted according to the hearing outcomes because of the possibility of improvement or deterioration. The etiological diagnosis of infants with mild-to-moderate SNHL would be helpful for predicting the outcome and managing intervention.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijporl.2023.111697 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and spectrum of STRC variants in 1015 sensorineural hearing loss patients: insights from the Chinese population.
Mol Genet Genomics
August 2025
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen Yang Road, Shanghai, 200031, China.
Mutations in the STRC gene are a major cause of autosomal recessive mild-to-moderate sensorineural hearing loss (SNHL); however, its prevalence and mutational spectrum in the Chinese population remain largely unexplored. To address this, we analyzed 1015 unrelated Chinese patients with bilateral SNHL using whole-exome sequencing (WES), multiplex ligation-dependent probe amplification (MLPA), and Sanger sequencing. Biallelic STRC variants were identified in 2.
View Article and Find Full Text PDFShort-Term Clinical and Biochemical Outcomes of Infants Born After 34 Weeks of Gestation with Mild-to-Moderate Cord Blood Acidosis-A Retrospective Study.
J Clin Med
August 2025
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
: Umbilical cord pH is used as a predictor of risk for poor neurologic outcome in high-risk newborns. While data on neonates with severe acidemia show a strong association with birth asphyxia and long-term adverse outcomes, the significance of mild-to-moderate acidemia is less clear. This study aimed to investigate short-term outcomes of late preterm and term infants born with mild-to-moderate cord blood acidosis and to compare the predictive ability of pH and base excess.
View Article and Find Full Text PDFAssessment of the ganglionic eminence in fetuses with isolated ventriculomegaly and its association with postnatal neurodevelopmental outcomes: a retrospective cohort study.
J Matern Fetal Neonatal Med
December 2025
Department of Obstetrics and Gynecology, Selcuk University Faculty of Medicine, Konya, Turkey.
Introduction: We aim to compare ganglionic eminence (GE) areas between healthy fetuses and those with isolated mild to moderate ventriculomegaly using Magnetic Resonance Imaging (MRI) and assess the postnatal implications of GE area as a marker for neurodevelopmental prognosis.
Material And Methods: A retrospective study was conducted on a cohort of pregnant women who underwent fetal MRI examination between 2018 and 2024. 104 fetuses with bilateral, isolated mild to moderate ventriculomegaly were included in the patient group, and 58 healthy fetuses were included in the control group.
Comparative Analysis of Pharmacological Treatments and Lifestyle Modifications for Managing Gastroesophageal Reflux Disease in Infants: A Literature Review.
Br J Hosp Med (Lond)
August 2025
Department of Medicine, Sofia Medical University, Sofia, Bulgaria.
Gastroesophageal reflux disease (GERD) is a common condition in infants, causing vomiting, irritability, and feeding difficulties. Though typically mild and self-limiting, severe cases may result in complications such as esophagitis, failure to thrive, or recurrent aspiration pneumonia. This review highlights a tiered approach to management, emphasizing non-pharmacological methods such as feeding adjustments, and thickened feeds as first-line treatments.
View Article and Find Full Text PDFObstetric brachial plexus injury: risk factors and clinical follow-up results.
J Turk Ger Gynecol Assoc
September 2025
Clinic of Obstetrics and Gynecology, University of Health Sciences Türkiye, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Türkiye.
Objective: Obstetric brachial plexus injury is a significant cause of neonatal morbidity. The aim of this study was to evaluate the maternal and perinatal factors associated with plexus injury and to analyze clinical follow-up outcomes and parental caregiving burden.
Material And Methods: This study was conducted as a retrospective descriptive study at the maternity center of a tertiary hospital.