Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Modifying biological agents with polymers such as polyethylene glycol (PEG) has demonstrated clinical benefits; however, post-market surveillance of PEGylated derivatives has revealed PEG-associated toxicity issues, prompting the search for alternatives. We explore how conjugating a poly-l-glutamic acid (PGA) to an anti-insulin growth factor 1 receptor antibody (AVE1642) modulates the bio-nano interface and anti-tumor activity in preclinical prostate cancer models. Native and PGA-modified AVE1642 display similar anti-tumor activity in vitro; however, AVE1642 prompts IGF-1R internalization while PGA conjugation prompts higher affinity IGF-1R binding, thereby inhibiting IGF-1R internalization and altering cell trafficking. AVE1642 attenuates phosphoinositide 3-kinase signaling, while PGA-AVE1642 inhibits phosphoinositide 3-kinase and mitogen-activated protein kinase signaling. PGA conjugation also enhances AVE1642's anti-tumor activity in an orthotopic prostate cancer mouse model, while PGA-AVE1642 induces more significant suppression of cancer cell proliferation/angiogenesis than AVE1642. These findings demonstrate that PGA conjugation modulates an antibody's bio-nano interface, mechanism of action, and therapeutic activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biomaterials.2023.122280 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic co-assembly of artificial carbon nanozyme and natural peroxidase to design dual active molecularly imprinted interface for endocrine disruptor's detection in industrial effluent.
Mikrochim Acta
August 2025
Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS University Islamabad, 1.5 Km Defense Road, Off Raiwind Road, Lahore Campus, Lahore, Punjab, 54000, Pakistan.
Molecular imprinting of artificial multi-walled carbon nanotubes (MWCNTs) nanozyme and natural horseradish peroxidase (HRP) enzyme on portable cellulose paper under UV light is reported to create a UV-cured HRP@MWCNTs sensing interface. The HRP@MWCNTs interface, having a target-specific site for phenols, catalyzed the oxidation of the colorless 3,3',5,5'-tetramethylbenzidine (TMB) to generate the oxidized TMB with visible blue color in the presence of exogenous hydrogen peroxide (HO). The binding of endocrine disruptors on the HRP@MWCNT surface inhibited the enzyme's active site for substrate oxidation, and subsequently color intensity was decreased.
View Article and Find Full Text PDFThermodynamic and electron paramagnetic resonance descriptors of TiO nanoforms interaction with plasma albumin: The interplay between energetic parameters and nanomaterial's toxicity.
Colloids Surf B Biointerfaces
July 2025
Institute of Physical Chemistry - Ilie Murgulescu of the Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania. Electronic address:
Protein-nanomaterial interaction is a topic of great interest for nanotechnology research, particularly for advancing strategies in nanomedicine and nanosafety. This study explores the thermodynamic signatures associated with the interactions of six TiO nanoforms, (differing in their crystalline structure, surface properties and particle size) with bovine serum albumin as model protein. By integrating findings from electron paramagnetic resonance spectroscopy (EPR) regarding the free radical generation following interaction, together with information on the stability and conformational changes of the protein during adsorption on TiO nanomaterials, we aim to elucidate the binding mechanisms and identify the primary factors influencing nanomaterial's reactivity.
View Article and Find Full Text PDFEngineered nanomaterials and macrophages: Toxicity mechanisms and protective strategies.
Int Immunopharmacol
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address:
Engineered nanomaterials (ENMs) have gained extensive applications across diverse fields, yet their potential cytotoxicity, particularly toward the immune system, raises significant safety concerns. As critical sentinels of innate immunity, macrophages directly interact with ENMs, making them pivotal targets for nanotoxicity studies. This review systematically addresses the interplay between ENMs and macrophages to advance their safe therapeutic utilization.
View Article and Find Full Text PDFA Wearable AI-Driven Mask with Humidity-Sensing Respiratory Microphone for Non-Vocal Communication.
Adv Sci (Weinh)
September 2025
International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Jilin, 130022, China.
Hoarseness and dysphonia caused by vocal cord conditions or laryngeal surgeries significantly hinder communication and quality of life. This study presents a plug-and-play humidity-sensing respiratory microphone (HSRM) with generalized features for individual users. Leveraging gold nanoparticle-based humidity sensors integrated into commercially available wearable face masks, the system enables patients to produce verbal communication without relying on vocal cord activity.
View Article and Find Full Text PDFUnveiling the Potential of Bioactive Glass in Volumetric Muscle Loss Regeneration.
Materials (Basel)
May 2025
Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Injuries characterized by significant loss of skeletal muscle tissue volume, known as volumetric muscle loss (VML), lead to substantial impairment in functional capabilities. Natural repair processes and existing medical interventions fall short of fully restoring function post-VML. Despite progress in the VML field, there is an unsatisfactory success rate, donor site morbidity, and inefficient reconstruction of lost muscle tissue.
View Article and Find Full Text PDF